Butriptyline
Butriptyline (Butriptylene) is an orally active tricyclic antidepressant that slightly enhances central 5-HT effects. Butriptyline does not inhibit brain norepinephrine uptake. Butriptyline can be used for depression research.
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- CAS No.: 35941-65-2
- Formule: C21H27N
- Masse moléculaire:293.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Butriptyline hydrochloride (2.5-30 mg/kg; i.p.; 10-15 day intervals) causes a dose dependent depression of the food reinforced responses and slightly depresses the avoidance reflex at the highest doses in male albino rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CFLP mice, monosodium glutamate (MSG)-induced obesity model[1]
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Dosage:1000 mg/kg
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Administration:In diet, 10 weeks
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Result:Significantly lowered the body weight.
Chemical Information
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CAS No. 35941-65-2
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Masse moléculaire 293.45
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Formule C21H27N
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SMILES
CC(CN(C)C)CC1C2=CC=CC=C2CCC3=C1C=CC=C3
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Synonyms
Butriptylene
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Pugsley TA, et al. Effect of butriptyline on the brain uptake mechanisms for noradrenaline and 5-hydroxytryptamine. J Pharm Pharmacol. 1974 Oct;26(10):778-8. [Content Brief]
[2]. Dulloo AG, et al. Screening of drugs for thermogenic anti-obesity properties: antidepressants. Ann Nutr Metab. 1987;31(2):69-80. [Content Brief]
[3]. Molinengo L, et al. The action of imipramine, amitriptyline, doxepin and butriptyline in an operant conditioning schedule. Psychopharmacologia. 1972;24(2):247-57. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Butriptyline Related Classifications
HY-A0175 Related Classifications
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