CF-Carvacrol
CF-Carvacrol is an orally active lipid-lowering agent synthesized by merging the pharmacophores of Carvacrol (HY-N0711) and Clofibric acid (HY-B1415). CF-Carvacrol has a good affinity for PPAR-α. CF-Carvacrol has significant hypolipidemic activity and may exert antioxidant and anti-inflammatory activity by activating the Nrf2/HO-1 signaling pathway to reduce liver injury. CF-Carvacrol can be used for the study of CF-induced liver damage.
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- Formule: C20H23ClO3
- Masse moléculaire:346.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hyperlipidemic KM mice induced by Triton WR 1339 (20 g)[1]
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Dosage:46.3, 92.6, 185.2 mg/kg
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Administration:i.g. daily for 7 days
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Result:Demonstrated notable efficacy in reducing lipid levels and showed reductions in TG levels by 37.5 % (185.2 mg/kg), 24.58 % (92.6 mg/kg ), and 19.31 % (46.3 mg/kg).
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Animal Model:KM mice (20 g)[1]
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Dosage:572.3 g/kg
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Administration:i.g. daily for a month
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Result:Increased the liver weight and showed lower hepatic injury compared with clofibrate (CF). Decreased ALT and AKP levels. Elevated the levels of plasma SOD and GSH. Elicited minimal oxidative stress response. Decreased TNF-α and IL-6 levels compared to the CF group. Showed no central venous congestion and extensive infiltration of inflammatory cells. Upregulated the expression of Nrf2 and HO-1 proteins.
Chemical Information
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Masse moléculaire 346.85
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Formule C20H23ClO3
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SMILES
CC(C1=CC(OC(C(C)(OC2=CC=C(C=C2)Cl)C)=O)=C(C=C1)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CF-Carvacrol Related Classifications
HY-175005 Related Classifications
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