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Elexacaftor

(Synonyms: VX-445)
51 Cited Publications
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Based on 51 publication(s) in Google Scholar

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.

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  • Pureté: 99.26%
  • CAS No.: 2216712-66-0
  • Formule: C26H34F3N7O4S
  • Masse moléculaire:597.65
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Elexacaftor Chemical Structure
    Elexacaftor Chemical Structure
  • Experimental Validation Results for Elexacaftor
  • Experimental Validation Results for Elexacaftor
  • Experimental Validation Results for Elexacaftor
  • Experimental Validation Results for Elexacaftor
  • Experimental Validation Results for Elexacaftor
  • Experimental Validation Results for Elexacaftor
CAS No.: 2216712-66-0
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  • Elexacaftor Chemical Structure
    Elexacaftor Chemical Structure
    1/16
  • 1/16

    Elexacaftor purchased from MedChemExpress. Usage Cited in: JCI Insight. 2026 Mar 23;11(6):e198846. [Abstract]

    Customer Validation
     Representative immunogold electron microscopy images showing the distribution of overexpressed F508del-CFTR-GFP in HEK293T cells. Cells were treated for 24 hours with DMSO (Veh), ETI (3 μM VX-445, 10 μM VX-661, and 1 μM VX-770) plus control peptide (ETI + 25 μM CP), or ETI plus PI3Kγ MP (ETI + 25 μM PI3Kγ MP). HEK293T cells expressing WT CFTR-GFP served as positive controls.

  • 1/16

    Elexacaftor purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 2:e176328. [Abstract]

    Customer Validation
     Subsequent to amiloride, short-circuit current (Isc) was increased by the C2 CFTR correctors VX-445 (10 μM).

  • 1/16

    Elexacaftor purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 2:e176328. [Abstract]

    Customer Validation
     Recording of force in millinewtons (mN) over time from a single mesenteric artery showing preconstriction with the prostaglandin mimetic U46619 (1 × 10−7 to 5 × 10−7 M), after which the ability of increasing concentrations of VX-445 (Elexacaftor) to induce vasorelaxation was assessed. We added 0 Ca2+ at the end to determine maximal vasorelaxation.

  • 1/16

    Elexacaftor purchased from MedChemExpress. Usage Cited in: J Cyst Fibros. 2023 May;22(3):525-537. [Abstract]

    Customer Validation
     Elexacaftor/Tezacaftor (elexa/teza; 3 μM/10 μM; 24 h) combination causes a significant increase in the expression of the mature protein, with no changes in the expression of the immature, core-glycosylated form (B band) in Epithelia.

  • 1/16

    Elexacaftor purchased from MedChemExpress. Usage Cited in: Am J Respir Crit Care Med. 2021 Nov 15;204(10):1231-1235. [Abstract]

    Customer Validation
     Western blot of CFTR variances transiently expressed in HEK293 (left) or CFBE (right) cells. Cells were transfected with indicated CFTR variances overnight and then treated with VX445 (Elexacaftor: 2 μM) /VX661 or DMSO for 24 hours.

  • 1/16

    Elexacaftor purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2021 Aug 16;131(16):e150398. [Abstract]

    Customer Validation
     Human airway epithelia from CFTR-ΔF508 donors were treated for 48 hours with a combination of elexacaftor (3 μM), tezacaftor (18 μM), and ivacaftor (1 μM), either alone or in the presence of TNF-α+IL-17. pHASL was measured using SNARF-1-dextran.

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