Gü1303
Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen.
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- CAS No.: 1043922-53-7
- Formule: C20H22N4O3
- Masse moléculaire:366.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Ki: 0.91 nM (mCatK)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LLC-MK2 | CC50 |
42 μM
Compound: Neq0677
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Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 34095840] |
| U2OS | CC50 |
10.2 μM
Compound: Neq0677
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 34095840] |
Chemical Information
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CAS No. 1043922-53-7
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Masse moléculaire 366.41
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Formule C20H22N4O3
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SMILES
CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gü1303 Related Classifications
HY-144812 Related Classifications
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