Gallein
Based on 10 publication(s) in Google Scholar
Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity[1][3].
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.0%
- CAS No.: 2103-64-2
- Formule: C20H12O7
- Masse moléculaire:364.31
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Gallein
More- Nature. 2026 Apr;652(8110):740-751. [Abstract]
- Nat Metab. 2024 Apr;6(4):708-723. [Abstract]
- Cell Death Dis. 2025 Aug 7;16(1):595. [Abstract]
- Pharmacol Res. 2023 May:191:106754. [Abstract]
- J Pineal Res. 2024 Jan;76(1):e12919. [Abstract]
- Front Immunol. 2021 Nov 24;12:786602. [Abstract]
- J Agric Food Chem. 2026 Apr 22;74(15):12132-12144. [Abstract]
- J Bone Miner Res. 2025 Nov 22:zjaf143. [Abstract]
- Water Biol Secur. 2025 Sep 18.
- Arch Biochem Biophys. 2025 Mar 27:768:110404. [Abstract]
Customer Validation & Images
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In Vivo Efficacy Study
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WB
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Activité biologique
Gβγ subunit
Gallein (10 μM, 0-150 h) inhibits β-ionone induced cell invasion in LNCaP prostate cancer cells[1]. Gallein (30 μM, 1 h) increases osteoprotegerin (OPG) synthesis induced by fibroblast growth factor 2 (FGF-2) in osteoblasts[2]. Gallein (25-50 μM, 24 h) inhibits platelet aggregation, secretion, and diffusion functions[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP cell
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Concentration:10 μM
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Incubation Time:0-150 h
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Result:Inhibited LNCaP cell invasion
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Cell Line:Osteoblast-like MC3T3-E1 cell
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Concentration:30 μM
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Incubation Time:1 h
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Result:Enhanced the FGF-2-induced OPG/Tnfrsf11b mRNA expression
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Cell Line:Platelet
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Concentration:25-50 μM
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Incubation Time:24 h
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Result:Reduced phosphorylation of Akt
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Castrated male NSG mice[1].
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection (i.p.); 15 days
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Result:Reduced the number of metastasised tissues
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Animal Model:C57BL/6 mice[3].
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Dosage:20 mg/kg
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Administration:Intravenous injection (i.v.); twice per day; 3 days
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Result:Extended tail bleeding time
Chemical Information
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CAS No. 2103-64-2
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Appearance Solid
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Masse moléculaire 364.31
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Formule C20H12O7
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Color Dark purple to black
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SMILES
O=C1OC2(C3=C(OC4=C2C=CC(O)=C4O)C(O)=C(O)C=C3)C5=C1C=CC=C5
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Synonyms
Pyrogallol phthalein
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (10)
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Journal Impact Factor
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Most Recent
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Nature
2026 Apr;652(8110):740-751. PMID: 41741641 -
Nat Metab
2024 Apr;6(4):708-723. PMID: 38499763
Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723. [Abstract]
Statistic result showing that in the SVF-derived adipocytes, treatment with inhibitor for Gαi (PTX) or Gβγ (Gallein, 10 μM, pretreated with 4 h) abolished the lactate-induced activation of ATF2.
Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723. [Abstract]
Representative western blots and statistical results showing that the lactate-induced activation of p38-ATF2 and upregulation of UCP1 were blocked by inhibitor for Gαi (PTX) or Gβγ (Gallein, 10 μM, pretreated with 4 h).
Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723. [Abstract]
Injection of inhibitor for p38 (SB203580), ROCK1 (Y-27632) or Gβγ (Gallein, 10 μM, pretreated with 4 h) into the inguinal fat pads in the tumour-bearing mice alleviated tumour-induced losses of body weight .
Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723. [Abstract]
Injection of inhibitor for p38 (SB203580), ROCK1 (Y-27632) or Gβγ (Gallein, 10 μM, pretreated with 4 h) into the inguinal fat pads in the tumour-bearing mice alleviated tumour-induced losses of tissue weights.
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Cell Death Dis
Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation. [Abstract]2025 Aug 7;16(1):595. PMID: 40774947 -
Pharmacol Res
G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation. [Abstract]2023 May:191:106754. PMID: 37019194 -
J Pineal Res
Melatonin alters the excitability of mouse cerebellar granule neurons by inhibiting voltage-gated sodium, potassium, and calcium channels. [Abstract]2024 Jan;76(1):e12919. PMID: 37794846 -
Front Immunol
Fpr2/CXCL1/2 Controls Rapid Neutrophil Infiltration to Inhibit Streptococcus agalactiae Infection. [Abstract]2021 Nov 24;12:786602. PMID: 34899755 -
J Agric Food Chem
Preventive Effect of Caffeic Acid Phenethyl Ester, an Active Component of Propolis, against TNF-α-Induced Endothelial Dysfunction through the β2-Adrenoceptor-Mediated eNOS/NO Signal Pathway. [Abstract]2026 Apr 22;74(15):12132-12144. PMID: 41957988 -
J Bone Miner Res
2025 Nov 22:zjaf143. PMID: 41273070 -
Gallein purchased from MedChemExpress. Usage Cited in: Water Biol Secur. 2025 Sep 18.
The percentage of mandarin fish ingesting live fish fry after 2-h immersion in the Gβγ signaling inhibitor Gallein (0.01, 0.1, and 1 μmol/L) across treatment groups.
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Arch Biochem Biophys
The odorant (R)-(-)-carvone promotes glucose-stimulated insulin secretion via the olfactory receptor Olfr1259 in pancreatic β-TC6 cells. [Abstract]2025 Mar 27:768:110404. PMID: 40157529
Solvant et solubilité
DMSO : 33.33 mg/mL (91.49 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. Gallein increases the fibroblast growth factor 2-elicited osteoprotegerin synthesis in osteoblasts. Biochim Biophys Acta Gen Subj. 2024 Aug;1868(8):130635. [Content Brief]
[3]. Alarabi AB, et al. The G-protein βγ subunits regulate platelet function. Life Sci. 2020 Dec 1;262:118481. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7449 mL | 13.7246 mL | 27.4492 mL | 68.6229 mL |
| 5 mM | 0.5490 mL | 2.7449 mL | 5.4898 mL | 13.7246 mL | |
| 10 mM | 0.2745 mL | 1.3725 mL | 2.7449 mL | 6.8623 mL | |
| 15 mM | 0.1830 mL | 0.9150 mL | 1.8299 mL | 4.5749 mL | |
| 20 mM | 0.1372 mL | 0.6862 mL | 1.3725 mL | 3.4311 mL | |
| 25 mM | 0.1098 mL | 0.5490 mL | 1.0980 mL | 2.7449 mL | |
| 30 mM | 0.0915 mL | 0.4575 mL | 0.9150 mL | 2.2874 mL | |
| 40 mM | 0.0686 mL | 0.3431 mL | 0.6862 mL | 1.7156 mL | |
| 50 mM | 0.0549 mL | 0.2745 mL | 0.5490 mL | 1.3725 mL | |
| 60 mM | 0.0457 mL | 0.2287 mL | 0.4575 mL | 1.1437 mL | |
| 80 mM | 0.0343 mL | 0.1716 mL | 0.3431 mL | 0.8578 mL |
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