γ-Cyhalothrin
γ-Cyhalothrin is an orally active, blood-brain barrier permeable Type II synthetic pyrethroid insecticide. γ-Cyhalothrin is the insecticidally active enantiomer of λ-Cyhalothrin (HY-B0836). γ-Cyhalothrin disrupts voltage-gated sodium channels, induces salivation and reduces spontaneous activity in rats. γ-Cyhalothrin exerts toxic effects on aquatic invertebrates and fish, triggers community-level effects in aquatic ecosystems, and inhibits host-seeking Ixodes scapularis nymphs in residential lawn ecotones. γ-Cyhalothrin is applicable to insecticidal-related research.
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- CAS No.: 76703-62-3
- Formule: C23H19ClF3NO3
- Masse moléculaire:449.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Gamma-cyhalothrin exhibits a median HC5 value of 0.47 ng/L for invertebrates, a median HC5 value of 23.7 ng/L for fish, and a no-observed-effect concentration at the community level (NOECcommunity) of 5 ng/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
γ-Cyhalothrin (0.0938-4 mg/kg; p.o.; single administration) dose-dependently reduces spontaneous activity and induces salivation in male Long-Evans rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:nymphal stage[2]
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Dosage:0.05% γ-Cyhalothrin, 362 g/92.9 m2 (equivalent to 292.5 mg active ingredient per 150 m2 plot)
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Administration:topical application; single dose
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Result:Reduced nymphal Ixodes scapularis density by 97.7% in Eau Claire County and 97.4% in Sauk County at 1 week postapplication.
Reduced density by 91.5% in Eau Claire County at 3 weeks and 89.5% at 4 weeks postapplication.
Reduced density by 90.9% in Sauk County at 2 weeks and 97.6% at 3 weeks postapplication.
Limited treated homes with at least one nymphal tick posttreatment to a range of 4.2% (Eau Claire County, week 1) to 29.2% (Eau Claire County, week 3), compared to 50-81.5% of placebo homes.
Lowered the odds of detecting a nymphal tick in treated plots to 0.04 times that of placebo plots at week 1 and 0.09 times that of placebo plots at week 3, after adjusting for plot characteristics and study area.
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Animal Model:Long-Evans (male, 63-67 days old, 331.1-361.7 g)[3]
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Dosage:0.0938 mg/kg, 0.188 mg/kg, 0.375 mg/kg, 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg; additional pilot doses: 0.3 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg
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Administration:p.o.; single dose
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Result:Produced statistically significant decreases in locomotor activity counts relative to controls at doses ≥0.75 mg/kg.
Achieved an ED50 of 1.29 mg/kg for reducing locomotor activity.
Reached a benchmark dose (BMD) of 0.256 mg/kg for a 1 standard deviation decrease in activity.
Induced salivation at 13% incidence with 0.75 mg/kg, 17% incidence with 1 mg/kg, 69% incidence with 1.5 mg/kg, 92% incidence with 2 mg/kg, and 100% incidence with 3 mg/kg and 4 mg/kg.
Associated a 50% decrease in locomotor activity with a plasma concentration of 486.1 ng/mL and a brain concentration of 13.37 ng/g.
Showed a strong positive linear correlation between brain and plasma concentrations, with both tissue levels correlating significantly with decreases in locomotor activity counts.
Chemical Information
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CAS No. 76703-62-3
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Masse moléculaire 449.85
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Formule C23H19ClF3NO3
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SMILES
C(=C(/C(F)(F)F)\Cl)\[C@H]1[C@@H](C(O[C@H](C#N)C2=CC(OC3=CC=CC=C3)=CC=C2)=O)C1(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Giddings JM, et al. Comparative aquatic toxicity of the pyrethroid insecticide lambda-cyhalothrin and its resolved isomer gamma-cyhalothrin. Ecotoxicology. 2009;18(2):239-249. [Content Brief]
[2]. Bron GM, et al. Do-It-Yourself Tick Control: Granular Gamma-Cyhalothrin Reduces Ixodes scapularis (Acari: Ixodidae) Nymphs in Residential Backyards. J Med Entomol. 2021;58(2):749-755. [Content Brief]
[3]. Moser VC, et al. Locomotor activity and tissue levels following acute administration of lambda- and gamma-cyhalothrin in rats. Toxicol Appl Pharmacol. 2016;313:97-103. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
γ-Cyhalothrin Related Classifications
HY-W743773 Related Classifications
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