PRMT3 - protein arginine methyltransferase 3 Gene

Also Known as HRMT1L3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10196

About PRMT3

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:20,387,716-20,509,338 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 7.5), brain (RPKM 3.3) and 25 other tissues.

Summary

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

PRMT3 Products (6)

mRNA	Protein	Name
XM_047426227.1	XP_047282183.1	protein arginine N-methyltransferase 3 isoform X1
NM_001145166.2	NP_001138638.1	protein arginine N-methyltransferase 3 isoform 2
NM_005788.4	NP_005779.1	protein arginine N-methyltransferase 3 isoform 1
XM_011519836.3	XP_011518138.1	protein arginine N-methyltransferase 3 isoform X2
XM_047426228.1	XP_047282184.1	protein arginine N-methyltransferase 3 isoform X3
NM_001145167.2	NP_001138639.1	protein arginine N-methyltransferase 3 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables methyltransferase activity	IDA IDA: Inferred from direct assay	18573314	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18573314	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	18573314	GOA
involved in negative regulation of retinoic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	33495566	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	33495566	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT3 Protein Structure

PrmA

0
100
200
300
400
500
531 a.a.

Protein Preferred Names	Protein Names
protein arginine N-methyltransferase 3	HMT1 hnRNP methyltransferase-like 3 heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3

PRMT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PRMT3	O60678	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
Intra	PRMT3	O60678	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	PRMT3	O60678	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	PRMT3	O60678	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	PRMT3	O60678	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	PRMT3	O60678	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	PRMT3	O60678	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	PRMT3	O60678	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PRMT3	O60678	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PRMT3	O60678	RPS2	Homo sapiens	P15880	TAP	24981860
Intra	PRMT3	O60678	RPS2	Homo sapiens	P15880	Validated Y2H	32296183
Intra	PRMT3	O60678	RPS2	Homo sapiens	P15880	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRMT3 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P76551	PRMT3 Protein, Human (His)	O60678-1 (C2-Q531)	≥ 95%, as determined by reducing SDS-PAGE.

PRMT3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81986	PRMT3 Antibody (YA1731)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P81986A	PRMT3 Antibody (YA1731)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Robinow Syndrome, Autosomal Dominant 2	Autosomal Dominant Robinow Syndrome 2 DRS2 Robinow, Autosomal Dominant Syndrome, Type 2
Oculopharyngeal Muscular Dystrophy	OPMD Muscular Dystrophy, Oculopharyngeal Dystrophy, Oculopharyngeal Muscular Oculopharyngeal Dystrophy Progressive Muscular Dystrophy, Oculopharyngeal Type Muscular Dystrophy Oculopharyngeal Dystrophy, Muscular, Oculopharyngeal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-128717A	GSK3368715 dihydrochloride	Inhibitor	99.96%	Phase 1
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-19615	MS023	Inhibitor	99.93%	Unkown
HY-19715	SGC707	Inhibitor	99.99%	Unkown
HY-128717	GSK3368715	Inhibitor	99.41%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.68%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-159732	PRMT3-IN-4	Inhibitor	/	Unkown
HY-184653	MS3-123	Inhibitor	/	Unkown
HY-159728	PROTAC PRMT3 degrader 1	Degrader	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-110158	UNC2327	Inhibitor	99.70%	Unkown
HY-171132	PRMT3-IN-5	Inhibitor	/	Unkown
HY-175821	PRMT1-IN-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRMT3	VGNC	VGNC:64359
Mus musculus	PRMT3	MGD	MGI:1919224
Rattus norvegicus	PRMT3	RGD	RGD:620413
Bos taurus	PRMT3	VGNC	VGNC:33349
Canis familiaris	PRMT3	VGNC	VGNC:44997
Others	PRMT3	NCBI