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Rhoa - ras homolog family member A Gene

Also Known as Arha; Arha1; Arha2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11848

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Rhoa Products (3)

mRNA	Protein	Name
NM_001313961.1	NP_001300890.1	transforming protein RhoA precursor
NM_001313962.1	NP_001300891.1	transforming protein RhoA precursor
NM_016802.5	NP_058082.2	transforming protein RhoA precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	10699171	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9214622	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	22019888	MGI
acts upstream of or within actin cytoskeleton organization	IDA IDA: Inferred from direct assay	1643657	MGI
involved in alpha-beta T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	25398325	MGI
acts upstream of or within androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	16254014	MGI
acts upstream of or within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	24335996	MGI
involved in apical junction assembly	IDA IDA: Inferred from direct assay	20974804	MGI
involved in beta selection	IMP IMP: Inferred from mutant phenotype	25398325	MGI
involved in bone trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	22019888	MGI
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	14657280	MGI
acts upstream of or within cell differentiation	IDA IDA: Inferred from direct assay	11877460	MGI
acts upstream of or within cell morphogenesis	IGI IGI: Inferred from genetic interaction	15860730	MGI
acts upstream of or within cell-matrix adhesion	IDA IDA: Inferred from direct assay	1643657	MGI
acts upstream of or within cerebral cortex cell migration	IMP IMP: Inferred from mutant phenotype	22405202	MGI
acts upstream of or within cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	22405202	MGI
acts upstream of or within forebrain radial glial cell differentiation	IMP IMP: Inferred from mutant phenotype	22405202	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	25071083	MGI
acts upstream of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15071095	MGI
involved in negative regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	18981818	MGI
acts upstream of or within negative regulation of intracellular steroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	16254014	MGI
acts upstream of or within negative regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15071095	MGI
involved in negative regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	25398325	MGI
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	25398325	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	22405202	MGI
involved in odontogenesis	IEP IEP: Inferred from expression pattern	25911094	MGI
involved in ossification involved in bone maturation	IMP IMP: Inferred from mutant phenotype	22019888	MGI
involved in positive regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	25398325	MGI
acts upstream of or within positive regulation of podosome assembly	IGI IGI: Inferred from genetic interaction	21525037	MGI
acts upstream of or within positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	25071083	MGI
acts upstream of or within positive regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	24335996	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25398325	MGI
involved in regulation of microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25398325	MGI
acts upstream of or within regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	22405202	MGI
acts upstream of or within regulation of neuron projection development	IDA IDA: Inferred from direct assay	21976490	MGI
involved in regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	22019888	MGI
acts upstream of or within regulation of systemic arterial blood pressure by endothelin	IMP IMP: Inferred from mutant phenotype	24335996	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18332105	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	22019888	MGI
acts upstream of or within skeletal muscle tissue development	IDA IDA: Inferred from direct assay	11877460	MGI
acts upstream of or within stress fiber assembly	IDA IDA: Inferred from direct assay	10699171	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in cytosol	IDA IDA: Inferred from direct assay	11877460	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	18824598	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15093731	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15093731	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	9214622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transforming protein RhoA	aplysia ras-related homolog A ras homolog gene family, member A

Rhoa Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	Rhoa	Q9QUI0	Rtkn	Mus musculus	Q8C6B2	Pull Down	21029865

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Nom du produit	Pureté	Rare Diseases
HY-10341	Fasudil Hydrochloride	99.97%	Yes
HY-10341A	Fasudil	99.98%	Yes
HY-109523	Cerivastatin sodium	99.89%	Unkown
HY-10341C	Fasudil dihydrochloride	99.98%	Yes
HY-10341B	Fasudil hydrochloride semihydrate	/	Unkown
HY-129458	Cerivastatin	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-I0400	N-Acetylneuraminic acid		99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-12646	Rhosin hydrochloride		99.94%	Unkown
HY-108566	U-46619	Agonist	99.61%	Unkown
HY-16563	Narciclasine	Activator	99.88%	Unkown
HY-12646A	Rhosin		98.74%	Unkown
HY-108361	CCG-203971	Inhibitor	99.89%	Unkown
HY-15477	YS-49		99.98%	Unkown
HY-12649	Y16	Inhibitor	98.12%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-135457	JMS-053	Inhibitor	98.0%	Unkown
HY-113849	MLS-573151	Inhibitor	99.66%	Unkown
HY-N0168A	(Rac)-Hesperetin	Inhibitor	99.28%	Unkown
HY-N2322	Khasianine	Inhibitor	99.11%	Unkown
HY-117548	UNC1062		98.92%	Unkown
HY-15477A	YS-49 monohydrate		99.56%	Unkown
HY-145915A	(E/Z)-ZINC09659342	Inhibitor	99.71%	Unkown
HY-168596	RhoA-ROCK-IN-1		98.40%	Unkown
HY-121667	Scaff10-8	Inhibitor	99.11%	Unkown
HY-RS11945	RHOA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N0168AS1	(Rac)-Hesperetin-13C,d3	Inhibitor	99.3%	Unkown
HY-139061	Palmitoyl 3-carbacyclic phosphatidic acid	Inhibitor	99.9%	Unkown
HY-P2325	Exoenzyme C3, clostridium botulinum	Inhibitor	/	Unkown
HY-N0168AS	(Rac)-Hesperetin-d3	Inhibitor	/	Unkown
HY-104023	ZK-Thiazolidinone	Inhibitor	/	Unkown
HY-109523S	Cerivastatin-d3 sodium		/	Unkown
HY-123958	SB772077B	Inhibitor	/	Unkown
HY-145915	ZINC09659342	Inhibitor	/	Unkown
HY-150187	20:4 Lyso PI		/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	Unkown
HY-180371	NF-115	Inducer	/	Unkown
HY-10341D	Fasudil mesylate		/	Unkown
HY-158652	(R)-CCG-1423	Inhibitor	/	Unkown
HY-N14739	Dykellic acid	Inhibitor	/	Unkown
HY-RS17004	Rhoa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23447	Rhoa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P990805	Anti-Human/Mouse GRP78 Antibody (C38)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rhoa	NCBI	NCBI:387