RHOA - ras homolog family member A Gene
Also Known as ARHA; ARH12; RHO12; EDFAOB; RHOH12
Species: Homo sapiens
About RHOA
This gene has 11 transcripts (splice variants), 129 orthologues, 22 paralogues and is associated with 81 phenotypes. Ubiquitous expression in fat (RPKM 218.4), lung (RPKM 210.7) and 25 other tissues.
Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
RHOA Products (7)
| mRNA | Protein | Name |
|---|---|---|
| NM_001313941.2 | NP_001300870.1 | transforming protein RhoA isoform 1 precursor |
| NM_001313943.2 | NP_001300872.1 | transforming protein RhoA isoform 2 |
| NM_001313944.2 | NP_001300873.1 | transforming protein RhoA isoform 3 |
| NM_001313945.2 | NP_001300874.1 | transforming protein RhoA isoform 4 |
| NM_001313946.2 | NP_001300875.1 | transforming protein RhoA isoform 5 |
| NM_001313947.2 | NP_001300876.1 | transforming protein RhoA isoform 6 |
| NM_001664.4 | NP_001655.1 | transforming protein RhoA isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables GTP binding |
IDA
IDA: Inferred from direct assay
|
12777804 | GOA |
| enables GTPase activity |
EXP
EXP: Inferred from Experiment
|
18829532 | GOA |
| enables GTPase activity |
IDA
IDA: Inferred from direct assay
|
19734146 | GOA |
| enables myosin binding |
IPI
IPI: Inferred from physical interaction
|
15644318 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9214622 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in apical junction complex |
IDA
IDA: Inferred from direct assay
|
20974804 | GOA |
| located in cell cortex |
IDA
IDA: Inferred from direct assay
|
16103226 | GOA |
| located in cell periphery |
IMP
IMP: Inferred from mutant phenotype
|
25911094 | GOA |
| colocalizes with cleavage furrow |
IDA
IDA: Inferred from direct assay
|
16103226 | GOA |
| located in cytoplasmic side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
1328215 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
1328215 | GOA |
| located in endosome |
IMP
IMP: Inferred from mutant phenotype
|
19887681 | GOA |
| is active in glutamatergic synapse |
IDA
IDA: Inferred from direct assay
|
21423166 | GOA |
| is active in glutamatergic synapse |
IMP
IMP: Inferred from mutant phenotype
|
21423166 | GOA |
| is active in postsynapse |
IDA
IDA: Inferred from direct assay
|
21423166 | GOA |
| is active in postsynapse |
IMP
IMP: Inferred from mutant phenotype
|
21423166 | GOA |
| located in vesicle |
IDA
IDA: Inferred from direct assay
|
19887681 | GOA |
RHOA Protein Structure
Ras: Ras family (7 - 179)
- 0
- 100
- 193 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
transforming protein RhoA |
|
RHOA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
RHOA | P61586 | SMAD2 | Homo sapiens | Q15796 | 20195357 | |
|
Cross
|
RHOA | P61586 | sseJ | Salmonella typhimurium | Q9FD10 | 19887681 | |
|
Cross
|
RHOA | P61586 | sseJ | Salmonella typhimurium | Q9FD10 | 19887681 | |
|
Cross
|
RHOA | P61586 | sseJ | Salmonella typhimurium | Q9FD10 | 19887681 | |
|
Cross
|
RHOA | P61586 | Rtkn | Mus musculus | Q8C6B2 | 21029865 | |
|
Intra
|
RHOA | P61586 | RIPOR3 | Homo sapiens | Q96MK2 | 32296183 | |
|
Intra
|
RHOA | P61586 | RIPOR3 | Homo sapiens | Q96MK2 | 32296183 | |
|
Intra
|
RHOA | P61586 | RIPOR3 | Homo sapiens | Q96MK2 | 32296183 | |
|
Intra
|
RHOA | P61586 | RIPOR2 | Homo sapiens | Q9Y4F9-2 | 32296183 | |
|
Intra
|
RHOA | P61586 | AGER | Homo sapiens | Q15109 | 19944695 | |
|
Intra
|
RHOA | P61586 | ANKS1B | Homo sapiens | Q7Z6G8-3 | 32296183 | |
|
Intra
|
RHOA | P61586 | ANKS1B | Homo sapiens | Q7Z6G8-3 | 32296183 | |
|
Intra
|
RHOA | P61586 | ANKS1B | Homo sapiens | Q7Z6G8-3 | 32296183 | |
|
Intra
|
RHOA | P61586 | RIPOR2 | Homo sapiens | Q9Y4F9 | 25416956 | |
|
Intra
|
RHOA | P61586 | RIPOR2 | Homo sapiens | Q9Y4F9 | 25416956 | |
|
Intra
|
RHOA | P61586 | DAAM1 | Homo sapiens | Q9Y4D1 | 18218625 | |
|
Intra
|
RHOA | P61586 | DAAM1 | Homo sapiens | Q9Y4D1 | 34591642 | |
|
Intra
|
RHOA | P61586 | DAAM1 | Homo sapiens | Q9Y4D1 | 33961781 | |
|
Intra
|
RHOA | P61586 | ARHGEF2 | Homo sapiens | Q92974 | 32296183 | |
|
Intra
|
RHOA | P61586 | ARHGEF2 | Homo sapiens | Q92974 | 33961781 | |
|
Intra
|
RHOA | P61586 | ARHGEF2 | Homo sapiens | Q92974 | 32296183 | |
|
Intra
|
RHOA | P61586 | ARHGEF2 | Homo sapiens | Q92974 | 32296183 | |
|
Intra
|
RHOA | P61586 | ARHGEF2 | Homo sapiens | Q92974 | 34591642 | |
|
Intra
|
RHOA | P61586 | ARHGEF11 | Homo sapiens | O15085 | 34591642 | |
|
Intra
|
RHOA | P61586 | ARHGEF11 | Homo sapiens | O15085 | 20300064 | |
|
Intra
|
RHOA | P61586 | ARHGEF11 | Homo sapiens | O15085 | 15530360 | |
|
Intra
|
RHOA | P61586 | ARHGEF11 | Homo sapiens | O15085 | 33961781 | |
|
Intra
|
RHOA | P61586 | ARHGEF11 | Homo sapiens | O15085 | 21988832 | |
|
Intra
|
RHOA | P61586 | ARHGEF11 | Homo sapiens | O15085 | 28514442 | |
|
Intra
|
RHOA | P61586 | NCL | Homo sapiens | P19338 | 21281639 | |
|
Intra
|
RHOA | P61586 | DIAPH1 | Homo sapiens | O60610 | 18218625 | |
|
Intra
|
RHOA | P61586 | RTKN | Homo sapiens | Q9BST9 | 12879077 | |
|
Intra
|
RHOA | P61586 | RTKN | Homo sapiens | Q9BST9 | 34591642 | |
|
Intra
|
RHOA | P61586 | RTKN | Homo sapiens | Q9BST9 | 19944695 | |
|
Intra
|
RHOA | P61586 | CDKN1B | Homo sapiens | P46527 | 19470470 | |
|
Intra
|
RHOA | P61586 | CDKN1B | Homo sapiens | P46527 | 19470470 | |
|
Cross
|
RHOA | P61586 | Mcf2l | Mus musculus | Q6PDM6 | 11889037 | |
|
Cross
|
RHOA | P61586 | Mcf2l | Mus musculus | Q6PDM6 | 12006984 | |
|
Intra
|
RHOA | P61586 | ARHGEF5 | Homo sapiens | Q12774 | 34591642 | |
|
Intra
|
RHOA | P61586 | ARHGAP1 | Homo sapiens | Q07960 | 31467278 | |
|
Intra
|
RHOA | P61586 | ARHGAP1 | Homo sapiens | Q07960 | 11927263 | |
|
Intra
|
RHOA | P61586 | ARHGAP1 | Homo sapiens | Q07960 | 16189514 | |
|
Intra
|
RHOA | P61586 | ARHGDIA | Homo sapiens | P52565 | 25416956 | |
|
Intra
|
RHOA | P61586 | ARHGDIA | Homo sapiens | P52565 | 20711218 | |
|
Intra
|
RHOA | P61586 | ARHGDIA | Homo sapiens | P52565 | 25416956 | |
|
Intra
|
RHOA | P61586 | ARHGDIA | Homo sapiens | P52565 | 35271311 | |
|
Intra
|
RHOA | P61586 | TRIP6 | Homo sapiens | Q15654 | 25416956 | |
|
Intra
|
RHOA | P61586 | IKZF3 | Homo sapiens | Q9UKT9 | 25416956 | |
|
Intra
|
RHOA | P61586 | IKZF3 | Homo sapiens | Q9UKT9 | 25416956 | |
|
Intra
|
RHOA | P61586 | ARHGEF12 | Homo sapiens | Q9NZN5 | 33961781 | |
|
Intra
|
RHOA | P61586 | ARHGEF12 | Homo sapiens | Q9NZN5 | 34591642 | |
|
Intra
|
RHOA | P61586 | SMURF1 | Homo sapiens | Q9HCE7-2 | 21708152 | |
|
Intra
|
RHOA | P61586 | SMURF1 | Homo sapiens | Q9HCE7-2 | 21708152 | |
|
Cross
|
RHOA | P61586 | sseJ | Salmonella typhimurium | A0A0F6B1Q8 | 22740689 |
Recombinant RHOA Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P73676 | RhoA Protein, Human (sf9, His) | P61586 (M1-L193) | ≥ 90%, as determined by reducing SDS-PAGE. |
RHOA Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P80311 | RhoA Antibody (YA093) | WB, ICC/IF, FC | Human, Mouse |
| HY-P80881 | RhoA Antibody | ICC/IF, WB, IHC-F, IHC-P, ELISA | Human, Mouse, Rat |
| HY-P80882 | RhoA/B/C Antibody | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
| HY-P84425 | RhoA Antibody (YA4122) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84425A | RhoA Antibody (YA4122)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P85713 | RhoA Antibody (YA5405) | IHC-P, WB | Human, Mouse, Rat |
| HY-P86646 | RhoA Antibody (YA6338) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ectodermal Dysplasia With Facial Dysmorphism And Acral, Ocular, And Brain Anomalies |
|
|
| Linear Hypopigmentation And Craniofacial Asymmetry With Acral, Ocular And Brain Anomalies |
|
|
| Hemihyperplasia, Isolated |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Adenocarcinoma |
|
|
| Gastric Adenocarcinoma |
|
|
| Plague |
|
|
| Esophageal Cancer |
|
|
| Ocular Hypertension |
|
|
| Lung Cancer |
|
|
| Breast Cancer |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Pulmonary Hypertension |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Colorectal Cancer |
|
|
| Tangier Disease |
|
|
| Endometrial Cancer |
|
|
| Angioimmunoblastic T-Cell Lymphoma |
|
|
| Glioblastoma |
|
|
| Fibrosarcoma |
|
|
| Arteriosclerosis |
|
|
| Pancreatic Cancer |
|
|
| Clostridium Difficile Colitis |
|
|
| Hepatocellular Carcinoma |
|
|
| Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis |
|
|
| Coronary Artery Vasospasm |
|
|
| Gastric Cancer |
|
|
| Prostate Cancer |
|
|
| Lissencephaly |
|
|
| Acute Megakaryocytic Leukemia |
|
|
| Cerebrocostomandibular Syndrome |
|
|
| Kidney Disease |
|
|
| Ectodermal Dysplasia |
|
|
| Mevalonic Aciduria |
|
|
| Bladder Cancer |
|
|
| Ovarian Cancer |
|
|
| Diffuse Gastric Cancer |
|
|
| Gastrointestinal Defects And Immunodeficiency Syndrome 1 |
|
|
| Asthma |
|
|
| Penile Disease |
|
|
| Osteoporosis |
|
|
| Hypertension, Essential |
|
|
| Scoliosis |
|
|
| Esophageal Leukoplakia |
|
|
| Neuroblastoma |
|
|
| Heart Disease |
|
|
| Periventricular Nodular Heterotopia |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Glaucoma, Primary Open Angle |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Interstitial Lung Disease 2 |
|
|
| Peripheral Nervous System Disease |
|
|
| Eye Disease |
|
|
| Nervous System Disease |
|
|
| Congenital Nervous System Abnormality |
|
|
| Dilated Cardiomyopathy |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | RHOA | VGNC | VGNC:33943 |
| Mus musculus | RHOA | MGD | MGI:1096342 |
| Felis catus | RHOA | VGNC | VGNC:68081 |
| Canis familiaris | RHOA | VGNC | VGNC:81924 |
| Rattus norvegicus | RHOA | RGD | RGD:619921 |
| Macaca mulatta | RHOA | VGNC | VGNC:84066 |
| Others | RHOA | NCBI |