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Cat. No.: HY-177776

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HDAC-IN-97

HDAC-IN-97 is a PROTAC HDAC6 degrader-6that can be used for synthesis of PROTACs, such as HDAC6 degrader-6 (HY-177758). HDAC6 degrader-6 is a potent HDAC6 PROTAC degrader with anticancer activity.

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CAS No.: 149647-86-9
Formule: C₈H₁₅NO₄
Masse moléculaire:189.21

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

HDAC-IN-97 Chemical Structure

CAS No.: 149647-86-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

HDAC6

Voir tous les produits spécifiques à Isoform HDAC :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
HT-29	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
Jurkat	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
K562	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
SK-BR-3	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
U-937	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]

Chemical Information

CAS No. 149647-86-9
Masse moléculaire 189.21
Formule C₈H₁₅NO₄
SMILES

O=C(CCCCCCC(O)=O)NO
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yang K, et al. A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders. Cell Chem Biol. 2020 Jul 16;27(7):866-876.e8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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HDAC-IN-97

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

HDAC-IN-97 Related Classifications

HY-177776 Related Classifications

Bioz

Keywords

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