ISP-VT
ISP-VT (Isopropyl vanillate) is a COX-2 inhibitor. ISP-VT exhibits anti-inflammatory, antipyretic and immunomodulatory activities. ISP-VT reduces neutrophil migration and the release of inflammatory factors. ISP-VT can be used for the research of inflammatory and immune diseases and other conditions.
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- CAS No.: 175796-45-9
- Formule: C11H14O4
- Masse moléculaire:210.23
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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COX-2 |
IL-6 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RBL-2H3 | IC50 |
415 μM
Compound: 4
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Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay
Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay
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[PMID: 27324979] |
ISP-VT (compound 4) (300 μM; 20 min) inhibits antigen-induced degranulation in RBL-2H3 cells, with an IC50 of 415 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ISP-VT (1 mg/kg; i.p.; single administration) exerts anti-inflammatory and antipyretic effects in Swiss mice through selective inhibition of COX-2, reduction of neutrophil migration, and suppression of inflammatory cytokine release[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice treated carrageenan (adult, both sexes, 25-30 g)[2]
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Dosage:0.3 mg/kg; 1 mg/kg; 3 mg/kg
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Administration:i.p.; single dose
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Result:Reduced paw edema by 53.5% at the 3-hour peak (1 mg/kg dose).
Reduced paw edema by 59.8% at the 3-hour peak (3 mg/kg dose).
Did not significantly reduce edema (0.3 mg/kg dose).
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Animal Model:Swiss mice (both sexes, 25-30 g) with carrageenan-induced paw edema, carrageenan-induced peritonitis, and Brewer’s yeast-induced hyperthermia[2]
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Dosage:1 mg/kg
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Administration:i.p.; single dose
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Result:Significantly reduced paw edema induced by carrageenan, dextran sulfate, compound 48/80, histamine, serotonin, bradykinin, and PGE2.
Decreased leukocyte and neutrophil recruitment, rolling, adhesion, and myeloperoxidase (MPO) activity.
Lowered TNF-α and IL-6 levels and vascular permeability, and downregulated COX-2 expression and selectively inhibited COX-2 activity.
Alleviated gastric toxicity compared with Indomethacin (HY-14397) and reduced rectal temperature in yeast-induced hyperthermic mice.
Chemical Information
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CAS No. 175796-45-9
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Masse moléculaire 210.23
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Formule C11H14O4
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SMILES
O=C(C1=CC=C(C(OC)=C1)O)OC(C)C
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Synonyms
Isopropyl vanillate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ishimata N, et al. Structure-activity relationships of vanillic acid ester analogs in inhibitory effect of antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3533-6. [Content Brief]
[2]. Nogueira KM, et al. Efficacy of a phenol derivative, isopropyl vanillate, as an anti-inflammatory agent: A new small molecule inhibitor of COX and neutrophil migration. Drug Dev Res. 2019;80(5):666-679. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ISP-VT Related Classifications
HY-182610 Related Classifications
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