KARI 101
KARI 101 is a blood-brain barrier permeable acid sphingomyelinase (ASM) inhibitor. KARI 101 directly inhibits ASM activity and reduces ceramide production. KARI 101 induces Ca2+ mobilization, activates AMPK and triggers GHSR1α internalization. KARI 101 can be used for the research of Alzheimer's disease.
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- CAS No.: 3061559-97-2
- Formule: C15H30N4O2
- Masse moléculaire:298.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
KARI 101 binds to purified acid sphingomyelinase (ASM) protein with high affinity[1].
KARI 101 inhibits the activity of secretory acid sphingomyelinase (ASM) in the supernatant of fibroblasts from PS1 familial Alzheimer's disease[1].
KARI 101 acts as a potent GHSR1α agonist in HEK293A cells overexpressing GHSR1α, with an EC50 of 188.5 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3061559-97-2
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Masse moléculaire 298.42
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Formule C15H30N4O2
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SMILES
OCC(C1=CN(CCCCCCCCCC)N=N1)(CO)N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KARI 101 Related Classifications
HY-186165 Related Classifications
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