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Cat. No.: HY-148171

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L-2'-Fd4C

L-2'-Fd4C, is an l-nucleoside analogue. L-2'-Fd4C has anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity.

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CAS No.: 221662-50-6
Formule: C₉H₁₀FN₃O₃
Masse moléculaire:227.19

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

L-2'-Fd4C Chemical Structure

CAS No.: 221662-50-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

L-2'-Fd4C, is an l-nucleoside analogue. L-2'-Fd4C has anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	>100 μM Compound: 23	Inhibitory activity was evaluated on mitochondrial DNA content of CEM cells Inhibitory activity was evaluated on mitochondrial DNA content of CEM cells	[PMID: 10197975]
PBMC	IC₅₀	>100 μM Compound: 23	Inhibitory activity was evaluated in human peripheral blood mononuclear (PBM) cells infected with Human immunodeficiency virus-1 Inhibitory activity was evaluated in human peripheral blood mononuclear (PBM) cells infected with Human immunodeficiency virus-1	[PMID: 10197975]
Vero	IC₅₀	>100 μM Compound: 23	Inhibitory activity was evaluated in Vero cells. Inhibitory activity was evaluated in Vero cells.	[PMID: 10197975]

In Vitro

L-2'-Fd4C (0-10 μM; 9 d; HepG2-2.2.15 cells) inhibits anti-hepatitis B virus (HBV) replication with an EC₅₀ value of 0.002 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-2'-Fd4C (100 mg/kg; i.p.; daily, for 7 d) has antihepadnavirus potency in HBV-transgenic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HBV-transgenic mice^[1]
Dosage:

100 mg/kg
Administration:

Intraperitoneal injection; daily, for 7 days
Result:

Had a reduction of HBV levels in their blood comparable to that produced by Lamivudine (HY-B0250).

Chemical Information

CAS No. 221662-50-6
Masse moléculaire 227.19
Formule C₉H₁₀FN₃O₃
SMILES

OC[C@@H]1O[C@H](N2C(N=C(C=C2)N)=O)C(F)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen H, et, al. Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine. Antimicrob Agents Chemother. 2003 Jun;47(6):1922-8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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L-2'-Fd4C

Voir tous les produits spécifiques à Isoform HIV

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis