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L-NAME

(Synonyms: NG-Nitroarginine methyl ester)
83 Cited Publications
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Based on 83 publication(s) in Google Scholar

L-NAME inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM. L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor. L-NAME can be used to induce hypertension and preeclampsia models.

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  • CAS No.: 50903-99-6
  • Formule: C7H15N5O4
  • Masse moléculaire:233.23
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • L-NAME Chemical Structure
    L-NAME Chemical Structure
  • Experimental Validation Results for L-NAME
  • Experimental Validation Results for L-NAME
  • Experimental Validation Results for L-NAME
CAS No.: 50903-99-6
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  • L-NAME Chemical Structure
    L-NAME Chemical Structure
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    L-NAME purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 May:161:114484. [Abstract]

    Customer Validation
     L-NAME (10 mg/kg; i.p.; single daily for 7 days; pretreat) alleviates Candesartan-induced glomerular shrinkage and renal tubular necrosis and detachment, in low-salt rats.

  • 1/16

    L-NAME purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2018 Aug;16(2):1079-1086. [Abstract]

    Customer Validation
     Effect of L-name on the expression of eNOS, HSP90, Nrf2, Nqo1 and HO-1 in a rat model of spinal cord injury (SCI).

  • 1/16

    L-NAME purchased from MedChemExpress. Usage Cited in: Bosn J Basic Med Sci. 2017 May 20;17(2):132-137. [Abstract]

    Customer Validation
     Effects of Akt/adenosine monophosphate-activated protein kinaseon CGP 48933 (VAL)-mediated endothelial nitric oxide (NO) synthase (eNOS) phosphorylation and NO production in human umbilical vein endothelial cells (HUVECs). (A) The variation of VAL (10 μM)-induced eNOS activation after HUVECs are incubated with LY294002 [LY] (10 μM), Compound C (1 μM), L-NAME (500 μM) for 3 hours. (B)The variation of VAL (10 μM)-induced nitric oxide (NO) productionafter HUVECs are incubated with LY294002 (10 μM),

  • L-NAME