LSD1-IN-32
LSD1-IN-32 (compound 11e) is a potent LSD1 inhibitor with an IC50 value of 0.99 µM. LSD1-IN-32 inhibits RANKL-induced osteoclastogenesis, bone resorption and F-actin belt formation. LSD1-IN-32 has the potential for the research of osteoporosis.
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- Formule: C36H56N2O3Si2
- Masse moléculaire:621.01
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
IC50: 0.99 µM (LSD1)[1]
LSD1-IN-32 (compound 11e) (1.25, 2.5, 5 µM) increases the methylation level during osteoclastogenesis in a dose-dependent manner[1].
LSD1-IN-32 (0.25, 0.5, 1, 2, 4 µM) inhibits RANKL-induced osteoclastogenesis, bone resorption and F-actin belt formation[1].
LSD1-IN-32 (2 µM; 0, 1, 2, 4 days) reduces the relative mRNA expression levels induced by RANKL of those genes of Acp5, Nfatc1, Oscar, Dc-stamp, Atp6v0d2, and Ctsk[1].
LSD1-IN-32 (0.5, 1, 2, 4 µM) inhibits the expressions of p-LSD1, p-IκB and p-NFκB in RANKL-induced osteoclastogenesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:osteoclasts
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Concentration:2 µM
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Incubation Time:0, 1, 2, 4 days
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Result:Reduced the relative mRNA expression levels of those genes (Acp5, Nfatc1, Oscar, Dc-stamp, Atp6v0d2, and Ctsk) induced by RANKL.
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Cell Line:osteoclasts
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Concentration:0.5, 1, 2, 4 µM
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Incubation Time:
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Result:Dose dependently inhibited the expressions of p-LSD1, p-IκB and p-NFκB in RANKL-induced osteoclastogenesis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:7-week-old C57BL/6 female mice (OVX (ovariectomy)-induced osteoporosis)[1]
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Dosage:5, 10 mg/kg
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Administration:I.p.; daily for four weeks
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Result:Significantly reduced the loss of the bone mass, reduced OVX-induced osteoclastic bone loss.
Chemical Information
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Masse moléculaire 621.01
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Formule C36H56N2O3Si2
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SMILES
O=C(N1CCC(CN[C@H]2[C@H](C3=CC=CC=C3)C2)CC1)/C=C/C4=CC=C(O[Si](C)(C(C)(C)C)C)C(O[Si](C)(C(C)(C)C)C)=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSD1-IN-32 Related Classifications
HY-161869 Related Classifications
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