Luotonin A
Based on 1 Customer Validation
Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 205989-12-4
- Formule: C18H11N3O
- Masse moléculaire:285.30
-
Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Topoisomerase
More
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
61.25 μM
Compound: 10
|
Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay
|
10.1007/s00044-012-0018-x |
| CCRF-CEM | GI50 |
≥40 μM
Compound: 1a, luotonin A
|
Growth inhibition of human CEM cells by Alamar blue assay
Growth inhibition of human CEM cells by Alamar blue assay
|
[PMID: 17418582] |
| CEM/C2 | GI50 |
>40 μM
Compound: 1a, luotonin A
|
Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay
Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay
|
[PMID: 17418582] |
| HCT-116 | IC50 |
51.11 μM
Compound: 36
|
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation
|
[PMID: 36375335] |
| HEK293 | IC50 |
58 μM
Compound: 1
|
Cytotoxicity against HEK cells after 72 hrs by MTT assay
Cytotoxicity against HEK cells after 72 hrs by MTT assay
|
[PMID: 25757092] |
| HeLa | GI50 |
3 μM
Compound: 1a, luotonin A
|
Growth inhibition of HeLa cells after 4 days
Growth inhibition of HeLa cells after 4 days
|
[PMID: 17418582] |
| HeLa | IC50 |
5.94 μM
Compound: 1
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 25757092] |
| HeLa | IC50 |
6.4 μM
Compound: 1
|
Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis
Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis
|
[PMID: 25757092] |
| HeLa | IC50 |
3 μM
Compound: 36
|
Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
|
[PMID: 36375335] |
| HL-60 | IC50 |
>100 μM
Compound: 36
|
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 36375335] |
| K562 | IC50 |
28.8 μM
Compound: 1
|
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
|
[PMID: 25757092] |
| MCF7 | GI50 |
3 μM
Compound: 1a, luotonin A
|
Growth inhibition of MCF7 cells after 4 days
Growth inhibition of MCF7 cells after 4 days
|
[PMID: 17418582] |
| MCF7 | GI50 |
5 μM
Compound: 1a, luotonin A
|
Growth inhibition of adriamycin-resistant MCF7 cells after 4 days
Growth inhibition of adriamycin-resistant MCF7 cells after 4 days
|
[PMID: 17418582] |
| MCF7 | IC50 |
9.28 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 25757092] |
| MCF7 | IC50 |
3 μM
Compound: 36
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 5 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 5 days by MTT assay
|
[PMID: 36375335] |
| NCI/ADR-RES | IC50 |
3 μM
Compound: 36
|
Antiproliferative activity against human NCI-ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
Antiproliferative activity against human NCI-ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
|
[PMID: 36375335] |
| NCI-H460 | IC50 |
67 μM
Compound: 1a
|
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)
|
[PMID: 15501036] |
| NCI-H460 | IC50 |
7.7 μM
Compound: 1a
|
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)
|
[PMID: 15501036] |
| NCI-H460 | IC50 |
7.7 μM
Compound: 36
|
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by SRB assay
|
[PMID: 36375335] |
| P388 | IC50 |
1.8 μg/mL
Compound: 1 (luotonin A)
|
Cytotoxic activity against mouse leukemia P-388 cells
Cytotoxic activity against mouse leukemia P-388 cells
|
[PMID: 14980663] |
| P388 | IC50 |
1.8 μg/mL
Compound: Luotonin A
|
Cytotoxicity against mouse P388 cells assessed as reduction in cell growth
Cytotoxicity against mouse P388 cells assessed as reduction in cell growth
|
[PMID: 30917303] |
| P388 | IC50 |
6.3 μM
Compound: 53
|
Antiproliferative activity gainst mouse P388 cells assessed as cell growth inhibition
Antiproliferative activity gainst mouse P388 cells assessed as cell growth inhibition
|
[PMID: 35413618] |
| P388 | IC50 |
1.8 μg/mL
Compound: 36
|
Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 36375335] |
| SK-N-SH | IC50 |
61.08 μM
Compound: 10
|
Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay
|
10.1007/s00044-012-0018-x |
Chemical Information
-
CAS No. 205989-12-4
-
Appearance Solid
-
Masse moléculaire 285.30
-
Formule C18H11N3O
-
Color White to off-white
-
SMILES
O=C1N2C(C3=C(C2)C=C4C(C=CC=C4)=N3)=NC5=CC=CC=C51
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
DMSO : 2.5 mg/mL (8.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
-
Fiche technique (274 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Hao Y, et al. Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents. J Agric Food Chem. 2020 Aug 19;68(33):8764-8773. [Content Brief]
[2]. Cagir A, et al. A naturally occurring human DNA topoisomerase I poison. J Am Chem Soc. 2003 Nov 12;125(45):13628-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5051 mL | 17.5254 mL | 35.0508 mL | 87.6271 mL |
| 5 mM | 0.7010 mL | 3.5051 mL | 7.0102 mL | 17.5254 mL |
Powered by Bioz