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Cat. No.: HY-165615

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M&B 4935

M&B 4935 is an orally active Amoebicide. M&B 4935 reduces the levels of *Entamoeba histolytica* parasites in rodents. M&B 4935 can be used for the research of amoebiasis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3613-83-0
Formule: C₁₀H₁₁Cl₂NO₃
Masse moléculaire:264.10

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

M&B 4935 Chemical Structure

CAS No.: 3613-83-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

M&B 4935 is an orally active Amoebicide. M&B 4935 reduces the levels of *Entamoeba histolytica* parasites in rodents. M&B 4935 can be used for the research of amoebiasis^[1].

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In Vitro

Parasitic Infection

M&B 4935 (24 h) exhibits amoebicidal activity against Entamoeba histolytica in vitro when tested as processed caecal extract, reducing the average Parasite Index to 0.3 and clearing 4/6 of test tubes of amoebae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parasitic Infection

M&B 4935 (1.0 g/kg; p.o.; 5 divided doses over 72 hours) exhibits in vivo amoebicidal activity in weanling rats with experimental Entamoeba histolytica caecal infection, reaching 74% of the activity of M&B 4321, and has a single-dose oral LD₅₀ of 1.5 g/kg in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Albino rats (weanling)^[1]
Dosage:

1.0 g/kg (total divided dose); 1.0 g/kg (single dose); 1.5 g/kg (LD50)
Administration:

p.o.; 5 divided doses over 72 hours; single dose
Result:

Demonstrated an in vivo amoebicidal activity of 74 relative to M&B 4321 (set at 100).
Resulted in an average Parasite Index of 0.3 (maximum index = 4.0) and cleared amoebae in 4 out of 6 microtubes at a single oral dose of 1.0 g/kg.
Had a single-dose oral LD50 of 1.5 g/kg in rats.

Chemical Information

CAS No. 3613-83-0
Masse moléculaire 264.10
Formule C₁₀H₁₁Cl₂NO₃
SMILES

O=C(N(C1=CC=C(O)C=C1)CCO)C(Cl)Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. KIDD DA, et al. Amoebicidal activity of dichloro-N-2-hydroxy-ethyl-N-p-methylsulphonylbenzylacetamide and some related compounds. Br J Pharmacol Chemother. 1962 Feb;18(1):128-37. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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