Manidipine
Based on 3 publication(s) in Google Scholar
Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy.
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- Pureté: 99.92%
- CAS No.: 89226-50-6
- Formule: C35H38N4O6
- Masse moléculaire:610.70
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Manidipine
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LLC-PK1 | IC50 |
4.6 μM
Compound: Manidipine
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TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
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[PMID: 11145223] |
| LLC-PK1 | IC50 |
4.65 μM
Compound: Manidipine
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TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells
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[PMID: 12128170] |
Manidipine (1 nM-1 μM; 1-4 h) inhibits the transcription of mRNA for IL-1β and GM-CSF, while enhancing the transcription of IL-6 gene in human mesangial cells stimulated by PDGF-BB[1].
Manidipine (0.1 nM-1 μM; 20-60 min) inhibits the ET-1-induced [Ca2+]i increase in A7r5 cells and glomerular mesangial cells[2].
Manidipine (1-5 μM; 18 h) completely inhibits IL-6 production induced by acLDL, oxLDL or TNF-α in human endothelial cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Manidipine (3 mg/kg; i.g.; once a day; 7 days) hydrochloride prevents Isoproterenol (HY-B0468)-induced left ventricular hypertrophy and the increase in ANP, collagen types I and III, and fibronectin mRNAs in rats[4].
Manidipine (0.05% in rat chow; p.o.; 2 months or 20 μg/kg; i.v.) hydrochloride shows antihypertensive effect in spontaneously hypertensive rats[5].
Manidipine (10-30 mg/kg; i.p.; before administration of agents that induced seizures) increases the latency to convulsions and the time of death in PTZ-induced seizure mice[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Spontaneously Hypertensive Rats (SHR) (age 8 weeks); Chronic hypertension renal microcirculation model and acute hypertension renal microcirculation model[5]
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Dosage:0.05% in rat chow (chronic), 20 μg/kg (acute)
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Administration:Oral administration (chronic, 2 months); Intravenous injection (acute, once)
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Result:Reduced systemic blood pressure, increased renal blood flow by dilating the afferent arterioles, and improved glomerular hypertension by dilating the efferent arterioles in the chronic model.
Decreased systemic blood pressure in the acute model.
Had different effects on renal microcirculation parameters, such as no significant change in SNGFR, SNGPF, or ΔP in some cases.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 89226-50-6
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Appearance Solid
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Masse moléculaire 610.70
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Formule C35H38N4O6
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Color Light yellow to yellow
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SMILES
O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Regulation of P-glycoprotein through CaMKII/cPLA2 pathway in lymphocytes for treating refractory rheumatoid arthritis by manidipine. [Abstract]2025 May 27:156:114735. PMID: 40294472 -
Biomed Pharmacother
Docking and database screening identify manidipine as a potential modulator of matrix metalloproteinase-7 in chronic kidney disease. [Abstract]2025 Dec:193:118748. PMID: 41232355 -
bioRxiv
2025 Nov 21:2025.11.20.689520. PMID: 41332603
Solvant et solubilité
DMSO : 100 mg/mL (163.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Roth M, et al. Manidipine regulates the transcription of cytokine genes. Proc Natl Acad Sci U S A. 1992 May 1;89(9):4071-5. [Content Brief]
[2]. Huang S, et al. Manidipine inhibits endothelin-1-induced [Ca2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells. Am Heart J. 1993 Feb;125(2 Pt 2):589-97. [Content Brief]
[3]. Costa S, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62(3):265-70. [Content Brief]
[4]. Yoshiyama M, et al. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Jpn Circ J. 1998 Jan;62(1):47-52. [Content Brief]
[5]. Tojo A, et al. Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1992 Dec;20(6):895-9. [Content Brief]
[6]. Rossoni G, et al. Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats. Eur J Pharmacol. 2008 Jun 10;587(1-3):224-30. [Content Brief]
[7]. Haraguchi K, et al. Catalepsy induced by manidipine, a calcium channel blocker, in mice. J Pharm Pharmacol. 1996 Apr;48(4):429-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6375 mL | 8.1873 mL | 16.3747 mL | 40.9366 mL |
| 5 mM | 0.3275 mL | 1.6375 mL | 3.2749 mL | 8.1873 mL | |
| 10 mM | 0.1637 mL | 0.8187 mL | 1.6375 mL | 4.0937 mL | |
| 15 mM | 0.1092 mL | 0.5458 mL | 1.0916 mL | 2.7291 mL | |
| 20 mM | 0.0819 mL | 0.4094 mL | 0.8187 mL | 2.0468 mL | |
| 25 mM | 0.0655 mL | 0.3275 mL | 0.6550 mL | 1.6375 mL | |
| 30 mM | 0.0546 mL | 0.2729 mL | 0.5458 mL | 1.3646 mL | |
| 40 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 1.0234 mL | |
| 50 mM | 0.0327 mL | 0.1637 mL | 0.3275 mL | 0.8187 mL | |
| 60 mM | 0.0273 mL | 0.1365 mL | 0.2729 mL | 0.6823 mL | |
| 80 mM | 0.0205 mL | 0.1023 mL | 0.2047 mL | 0.5117 mL | |
| 100 mM | 0.0164 mL | 0.0819 mL | 0.1637 mL | 0.4094 mL |
Manidipine Related Classifications
HY-B0419 Related Classifications
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