Morindone
Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer.
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- CAS No.: 478-29-5
- Formule: C15H10O5
- Masse moléculaire:270.24
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Activité biologique
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DNA Polymerase |
Morindone (0.39-50 μM, 24-72 h) inhibits the proliferation of KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells[1].
Morindone (10.7-19.2 μM, 72 h) induces apoptosis in HCT116 and HT29 cells[1].
Morindone (10.7-19.2 μM, 24-72 h) induces G1 phase arrest in HCT116 and HT29 cells[1].
Morindone (10.7-19.2 μM, 72 h) downregulates mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells, and downregulates mutated TP53 and BAX, while upregulates p21 in HT29 cells[1].
Morindone (28.1-35.9 μM, 60 mins) inhibits the activities of animal A-family, B-family and Y-family DNA polymerases with IC50 values of 28.1-35.9 μM[2].
Morindone (24 h) inhibits the proliferation of human colon cancer HCT116 cells with an LD50of 32.2 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells
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Concentration:0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 and 50 μM
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Incubation Time:24, 48 and 72 h
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Result:Showed 3.06% proliferation inhibition in HCT116 cells at 3.12 μM for 24 h and complete proliferation inhibition at 50 μM for 72 h.
Exhibited 20.5% inhibition at 0.78 μM for 24 h and over 90% inhibition at 12.5-50 μM for 72 h in HT29 cells.
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Cell Line:HCT116 and HT29 cells
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Concentration:10.7 μM for HCT116, 19.2 μM for HT29
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Incubation Time:72 h
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Result:Downregulated mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells.
Downregulated mutated TP53 and BAX, while upregulates p21 in HT29 cells.
Chemical Information
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CAS No. 478-29-5
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Masse moléculaire 270.24
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Formule C15H10O5
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SMILES
O=C1C2=CC=C(C)C(O)=C2C(C3=CC=C(C(O)=C13)O)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Morindone Related Classifications
HY-178224 Related Classifications
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