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Cat. No.: HY-123391

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PD 127443

PD 127443 is an inhibitor of 5-lipoxygenase and cyclooxygenase. PD 127443 has anti-inflammatory activity.

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CAS No.: 121502-05-4
Formule: C₂₀H₂₈N₂O
Masse moléculaire:312.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PD 127443 Chemical Structure

CAS No.: 121502-05-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PD 127443 is an inhibitor of 5-lipoxygenase and cyclooxygenase. PD 127443 has anti-inflammatory activity^[1].

Voir tous les produits spécifiques à Isoform Lipoxygenase :

Voir tous les produits spécifiques à Isoform COX :

Cellular Effect

Cell Line	Type	Value	Description	References
RBL-1	IC₅₀	0.9 μM Compound: 33	Inhibitory activity against cyclooxygenase in rat basophilic leukemia cells using prostaglandin G/H synthase assay Inhibitory activity against cyclooxygenase in rat basophilic leukemia cells using prostaglandin G/H synthase assay	[PMID: 1847426]
RBL-1	IC₅₀	3 μM Compound: 33	Inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells Inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells	[PMID: 1847426]

Chemical Information

CAS No. 121502-05-4
Masse moléculaire 312.45
Formule C₂₀H₂₈N₂O
SMILES

OC1=C(C=C(C=C1C(C)(C)C)/C=C/C2=NNC(C)=C2)C(C)(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Schrier DJ, et al. The in vivo antiinflammatory effects of (E)-2,6-bis(1,1-dimethyl-ethyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethenyl ] phenol (PD 127443) a novel dual inhibitor of 5-lipoxygenase and cyclooxygenase. Agents Actions. 1989 Jun;27(3-4):391-4. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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PD 127443

Voir tous les produits spécifiques à Isoform Lipoxygenase

Voir tous les produits spécifiques à Isoform COX