PF-03622905
PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases.
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- CAS No.: 1072100-15-2
- Formule: C24H35N7O3
- Masse moléculaire:469.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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PKCα 5.6 nM (IC50) |
PKCβI 14.5 nM (IC50) |
PKCβII 13 nM (IC50) |
PKCγ 37.7 nM (IC50) |
PKCθ 74.1 nM (IC50) |
PF-03622905 causes concentration-dependent inhibition of phospho-ERK1/2 formation, interleukin 8 release, and phospho-SHP2 levels with an IC50 value 0.15 μM, 0.16 μM, and 35 nM, respectively[1].
PF-03622905 shows low cytotoxicity at 1 μM against human umbilical vein endothelial cells with remaining cell viability at 83.3% viable[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1072100-15-2
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Masse moléculaire 469.58
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Formule C24H35N7O3
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SMILES
O=C(C1=CC=CC=N1)NC2=NNC3=C2CN(C(N4C[C@H](N(C[C@@H]4C)CCC)CCO)=O)C3(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-03622905 Related Classifications
HY-139466 Related Classifications
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