Piperitenone oxide
Piperitenone oxide is an orally active monoterpene ketone. Piperitenone oxide can be isolated from the essential oils of plants belonging to Mentha x villosa and Ziziphora clinopodioides. Piperitenone oxide induces differentiation. Piperitenone oxide induces chromosome breakage damage, aneuploidy damage and DNA single-strand breaks. Piperitenone oxide reduces ET-1 levels. Piperitenone oxide exerts antihypertensive effects. Piperitenone oxide can be used in studies related to colon cancer.
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- CAS No.: 3564-96-3
- Formule: C10H14O2
- Masse moléculaire:166.22
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Description
In Vitro
Piperitenone oxide (10-150 μM; 24 h) induces chromosome breakage or aneuploidy damage in HepG2 cells, resulting in a statistically significant concentration-dependent increase in micronucleus frequency[2].
Piperitenone oxide (30-150 μM; 24 h) induces single-strand DNA breaks or alkali-labile sites in HepG2 cells, resulting in a statistically significant, concentration-dependent increase in the percentage of DNA tail[2].
Piperitenone oxide (0.03-10 μg/mL; 24 h) dose-dependently inhibits norepinephrine-enhanced ET-1 secretion in primary bovine aortic endothelial cells (BAECs)[3].
Piperitenone oxide (50-100 pmol/L; 24 h) has no effect on NO production in norepinephrine-treated primary bovine aortic endothelial cells (BAECs)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SHR (male, 12-week-old)[3]
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Dosage:1 mg/kg; 10 mg/kg; 100 mg/kg
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Administration:p.o.
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Result:Reduced systolic blood pressure to 203.1 ± 7.9 mmHg (no significant difference vs.
control SHR) at 1 mg/kg.
Reduced systolic blood pressure to 180.7 ± 8.5 mmHg (p < 0.05 vs.
control SHR) at 10 mg/kg.
Reduced systolic blood pressure to 145.8 ± 7.7 mmHg (p < 0.01 vs.
control SHR) at 100 mg/kg.
Caused a dose-dependent reduction in serum ET-1 levels in SHR.
Chemical Information
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CAS No. 3564-96-3
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Masse moléculaire 166.22
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Formule C10H14O2
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SMILES
O=C1[C@@]2([H])O[C@@]2(C)CC/C1=C(C)/C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piperitenone oxide Related Classifications
HY-134013 Related Classifications
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