TrkA
TrkA, encoded by the NTRK1 gene, is the high-affinity receptor tyrosine kinase for nerve growth factor (NGF). Ligand-induced dimerization activates the intracellular kinase and initiates RAS/MAPK, PI3K/AKT, and PLC-gamma signaling that supports survival and differentiation of sympathetic and sensory neurons during development. Inactivating mutations of NTRK1 cause congenital insensitivity to pain with anhidrosis, a rare disorder characterized by loss of pain perception and impaired thermoregulation. Chromosomal rearrangements generating NTRK1 fusion proteins with constitutive kinase activity occur in papillary thyroid carcinoma, infantile fibrosarcoma, and other tumors, and are targetable with TRK inhibitors such as larotrectinib and entrectinib.
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TrkA Protéines Recombinantes (15)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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