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Cat. No.: HY-184447

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RN193

RN193 is a type II kinase inhibitor with a human PAK1 IC₅₀ of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1, PAK2, and PAK3, and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1, GSK3B, ULK1, MELK, MAPK13, BRAF, and STK10, indicating binding and stabilization of these proteins. RN193 induces formation of PAK3:PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states.

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CAS No.: 3091508-49-2
Formule: C₃₀H₃₂N₆O₃
Masse moléculaire:524.61

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Please store the product under the recommended conditions in the Certificate of Analysis.

RN193 Chemical Structure

CAS No.: 3091508-49-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
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Description

IC₅₀ & Target^[1]

PAK1^M248-H545

4.25 μM (IC₅₀)

PAK2

PAK3

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In Vitro

RN193 (2 h) potently and selectively binds to the truncated kinase domains of group I PAK1, PAK2, and PAK3 in 293T cells, with IC₅₀ values ranging from 0.14 to 0.16 μM^[1].
RN193 (2 h) inhibits the kinase activity of purified PAK1^M248-H545 with an IC₅₀ of 4.28 μM in an in vitro ADP-Glo assay^[1].
RN193 (2 h) induces the formation of PAK3:PAK2 heterodimers in live HEK293T cells with an IC₅₀ of 0.38 μM; it also disrupts PAK2:PAK2 homodimers with an IC₅₀ of 0.42 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3091508-49-2
Masse moléculaire 524.61
Formule C₃₀H₃₂N₆O₃
SMILES

O=C(C1(CC1)C(NC2=CC(C(C)C)=CC=C2)=O)NC3=CC(C4=CNC5=NC=NC(N6CCOCC6)=C54)=CC=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ehret TAL, et al. p21-Activated Kinase (PAK) Group I-Targeting Inhibitors Promote the Dimeric Conformation in Live Cells. ACS chemical biology. 2026 Jun 13. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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RN193

Voir tous les produits spécifiques à Isoform PAK

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Chemical Information

Pureté et documentation

Références

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RN193 Related Classifications

HY-184447 Related Classifications