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Cat. No.: HY-181289

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SelDeg51

SelDeg51 is a selective FKBP51 PROTAC degrader with a K_d value of 18 nM and a D_max of 90%. SelDeg51 induces proteasomal degradation of FKBP51 via the FKBP51:SelDeg51:VCB ternary complex and reactivates the glucocorticoid receptor signaling pathway. SelDeg51 can be used for research on stress-related mental disorders, chronic pain, and obesity.
(Pink: Target protein ligand; Blue: VHL ligand (HY-125905); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3036372-80-9
Formule: C₇₂H₉₁FN₈O₁₄S
Masse moléculaire:1343.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SelDeg51 Chemical Structure

CAS No.: 3036372-80-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

SelDeg51 is a selective FKBP51 PROTAC degrader with a K_d value of 18 nM and a D_max of 90%. SelDeg51 induces proteasomal degradation of FKBP51 via the FKBP51:SelDeg51:VCB ternary complex and reactivates the glucocorticoid receptor signaling pathway. SelDeg51 can be used for research on stress-related mental disorders, chronic pain, and obesity^[1]. (Pink: Target protein ligand; Blue: VHL ligand (HY-125905); Black: linker).

IC₅₀ & Target

^[1]

VHL	FKBP51 18 nM (Kd)

Voir tous les produits spécifiques à Isoform PROTACs :

In Vitro

SelDeg51 (0.6-10 μM; 0-48 h) degrades FKBP51 in a time-dependent and reversible manner in HEK293T cells, with high selectivity for FKBP12^[1].
SelDeg51 (250 nM) enhances Dexamethasone (HY-14648)-induced expression of endogenous glucocorticoid receptor target genes GILZ and FKBP5 in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T cells
Concentration:

1 μM
Incubation Time:

0, 2, 4, 6, 8, 24 and 48 h
Result:

Reduced FKBP51 protein levels.
Did not affact FKBP12 protein levels.

Chemical Information

CAS No. 3036372-80-9
Masse moléculaire 1343.60
Formule C₇₂H₉₁FN₈O₁₄S
SMILES

O=C(N1CCCC[C@H]1C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC=C(OCC4=CN(CCCOC5=C(CNC([C@@H]6C[C@@H](O)CN6C([C@H](C(C)(C)C)NC(C7(CC7)F)=O)=O)=O)C=CC(C8=C(C)N=CS8)=C5)N=N4)C=C3)=O)[C@H](C9=CC(OC)=C(OC)C(OC)=C9)C%10CCCCC%10
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Geiger TM, et al. Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51). Angew Chem Int Ed Engl. 2024;63(3):e202309706. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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SelDeg51

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SelDeg51 Related Classifications

HY-181289 Related Classifications

Bioz

Keywords

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