Selicrelumab
Based on 1 Customer Validation
Selicrelumab is an agonist CD40 antibody, induces changes in the tumor microenvironment. Selicrelumab can be used for the research of pancreatic cance and neoadjuvant study.
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- Pureté: 99.29%
- CAS No.: 1622140-49-1
- Masse moléculaire:146.2 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Human IgG2 kappa
Human
CD40
Selicrelumab (10 µg/mL, 2-3 days) activates the CD40 receptor on chronic lymphocytic leukemia (CLL) cells, upregulates co-stimulatory molecules (CD86), cytokines (TNF-α) and death receptors (CD95) in primary CLL cells[2].
Selicrelumab (10 µg/mL, 2 days) promotes the expression of anti-apoptotic protein MCL-1, induces resistance to Venetoclax (HY-15531) in CLL cells[2].
Selicrelumab (10 µg/mL, 2 days) enhances the sensitivity of CLL cells to GA101 (HY-P9910)-induced cell death through a lysosome-mediated mechanism[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:primary CLL cell
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Concentration:10 µg/mL
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Incubation Time:2 days
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Result:Upregulated the expression of Mcl-1.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
P25942-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG2 kappa
ELISA, FACS, Functional assay
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Flow Cytometry analysis of Raji cells labelling CD40 (red) with Selicrelumab (anti-CD40) (HY-P99046). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG2 kappa (HY-P99002). Black-Unlabelled control, cells without incubation with primary antibody. -
Immobilized CD40 Protein, Human can bind Selicrelumab. The EC50 for this effect is 22.34 ng/mL.
Chemical Information
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CAS No. 1622140-49-1
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Appearance Liquid
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Masse moléculaire 146.2 kDa
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Color Colorless to light yellow
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SMILES
[Selicrelumab]
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Synonyms
CP-870893; RG-7876
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
[1]. Katelyn T Byrne, Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer. Clin Cancer Res. 2021 Aug 15;27(16):4574-4586. [Content Brief]
[2]. Delgado R, et al., Co-Stimulatory versus Cell Death Aspects of Agonistic CD40 Monoclonal Antibody Selicrelumab in Chronic Lymphocytic Leukemia. Cancers (Basel). 2021 Jun 21;13(12):3084. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Selicrelumab Related Classifications
HY-P99046 Related Classifications
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