Sennoside
Sennoside is an orally active apoptosis inducer and stimulant laxative, found in Senna (Cassia angustifolia). Sennoside induces overexpression of wild-type p53 and p21/WAF as part of pathways mediating colonic epithelial cell apoptosis. Sennoside stimulates colonic peristalsis, reverses net water, sodium, chloride absorption to secretion and enhances potassium and calcium secretion. Sennoside increases paracellular permeability to small molecules, accelerates colon transit and softens fecal pellets. Sennoside can be used for the research of constipation, melanosis coli, and colorectal cancer.
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- CAS No.: 517-43-1
- Formule: C42H38O20
- Masse moléculaire:862.74
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Sennoside (50 mg/kg; p.o.; single dose) transiently elevates paracellular permeability at 6 hours, does not induce significant epithelial cell damage or alter cAMP pathway activity, and not affect Na+, K+-ATPase activity overall[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (female, ~200 g body weight)[3]
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Dosage:50 mg/kg
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Administration:p.o.; single dose
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Result:Showed no change in net H2O, Na+, Cl-, and K+ absorption/secretion from controls at 2 and 4 hours post-treatment.
Reversed net H2O, Na+, and Cl- absorption to net secretion at 6 hours (H2O: -0.34 mL/10 cm colon/h, Na+: -44 μmol/10 cm colon/h, Cl-: -32 μmol/10 cm colon/h; all p ≤ 0.001 vs controls).
Increased net K+ secretion to -15.3 μmol/10 cm colon/h at 6 hours (p ≤ 0.05 vs controls).
Increased net Ca2+ secretion to -1.14 μmol/10 cm colon/h at 6 hours (p ≤ 0.01 vs controls).
Increased paracellular permeability to 3-fold higher than controls at 6 hours (-336 μl/10 cm colon/h, p ≤ 0.001 vs controls).
Showed persistent but diminished net H2O and Na+ secretion at 12 hours (H2O: -0.51 mL/10 cm colon/h, Na+: -13 μmol/10 cm colon/h; both p ≤ 0.001 vs controls), while Cl- returned to net absorption (9 μmol/10 cm colon/h, p ≤ 0.001 vs controls).
Increased net K+ secretion to -22.8 μmol/10 cm colon/h at 12 hours (p ≤ 0.001 vs controls).
Increased net Ca2+ secretion to -0.97 μmol/10 cm colon/h at 12 hours (p ≤ 0.001 vs controls).
Showed persistent reduced net H2O secretion at 24 hours (-0.20 mL/10 cm colon/h, p ≤ 0.001 vs controls), while Na+ and Cl- showed net absorption (Na+: 18 μmol/10 cm colon/h, Cl-: 34 μmol/10 cm colon/h; both p ≤ 0.001 vs controls).
Increased net K+ secretion to -23.9 μmol/10 cm colon/h at 24 hours (p ≤ 0.001 vs controls).
Increased net Ca2+ secretion to -1.18 μmol/10 cm colon/h at 24 hours (p ≤ 0.001 vs controls).
Showed no significant increase in LDH leakage into the colon lumen at any time point post-treatment.
Showed unchanged Na+, K+-ATPase activity at 4 and 6 hours, with a statistically significant but inconsistent reduction at 24 hours (568 nmol Pi/mg protein/10 min, p ≤ 0.001 vs controls).
Showed unchanged colon mucosal cAMP content and phosphodiesterase activity at 6 hours post-treatment.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 517-43-1
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Masse moléculaire 862.74
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Formule C42H38O20
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SMILES
OC[C@@H](O1)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC=CC3=C2C(C4=C(C=C(C(O)=O)C=C4O)C3C5C6=C(C(C7=C5C=C(C(O)=O)C=C7O)=O)C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=CC=C6)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. van Gorkom BA, et al. Apoptosis induction by sennoside laxatives in man; escape from a protective mechanism during chronic sennoside use?. J Pathol. 2001;194(4):493-499. [Content Brief]
[2]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [Content Brief]
[3]. Leng-Peschlow E. Sennoside-induced secretion and its relevance for the laxative effect. Pharmacology. 1993 Oct;47 Suppl 1:14-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sennoside Related Classifications
HY-N12281 Related Classifications
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