SRT6
SRT6 is a CD44 inhibitor. SRT6 exerts antiproliferative activity in CD44+ breast cancer and lung cancer cells. SRT6 inhibits CD44-associated SRC kinase, as well as EGFR, ERBB2, ERBB4, MAP3K10 and MAPKAPK2. SRT6 can be used for the research of breast cancer and lung cancer.
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- Formule: C25H26N2O8S
- Masse moléculaire:514.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
SRT6 (0.01-100 μM; 5 days) inhibits the proliferation of CD44+ MDA-MB-231, A549, and NCI-H23 cells, with EC50 values of 7.57, 5, and 1.37 μM, respectively[1].
The antiproliferative activity of SRT6 (7.57 μM; 5 days) against MDA-MB-231 breast cancer cells decreases by 13% after blocking CD44 with an anti-CD44 antibody, confirming that this activity is mediated by CD44[1].
SRT6 (5 μM-50 μM) potently inhibits CD44-associated SRC kinase, and also inhibits EGFR, ERBB2, ERBB4, MAP3K10 and MAPKAPK2 at a concentration of 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CD44+ MDA-MB-231 human breast adenocarcinoma cells
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Concentration:0.01-100 μM
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Incubation Time:5 days
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Result:Inhibited MDA-MB-231 cell proliferation with an EC50 of 7.57 μM, as calculated from 10-point semilog dose-response curves.
Inhibited A549 cell proliferation with an EC50 of 5.00 μM, as calculated from 10-point semilog dose-response curves.
Inhibited NCI-H23 cell proliferation with an EC50 of 1.37 μM, as calculated from 10-point semilog dose-response curves.
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Cell Line:CD44+ MDA-MB-231 human breast adenocarcinoma cells
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Concentration:7.57 μM
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Incubation Time:5 days (SRT6 incubation); 30 min (anti-CD44 antibody pre-incubation)
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Result:Had its antiproliferative activity reduced by 13% compared to cells treated with SRT6 alone, confirming CD44 as a primary target.
Chemical Information
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Masse moléculaire 514.55
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Formule C25H26N2O8S
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SMILES
O=S(C1=CC=C([N+]([O-])=O)C=C1)(OC2=CC=CC3=C2CCN(CC4=CC(OC)=C(OC)C(OC)=C4)C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SRT6 Related Classifications
HY-175809 Related Classifications
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