Tiropramide
Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia.
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- CAS No.: 55837-29-1
- Formule: C28H41N3O3
- Masse moléculaire:467.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Tiropramide inhibits phosphodiesterase activity in rabbit colon homogenates and increases ATP- and Mg2+-dependent calcium binding to rabbit colon sarcoplasmic reticulum microsomal fractions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 55837-29-1
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Masse moléculaire 467.64
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Formule C28H41N3O3
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SMILES
O=C(C(CC1=CC=C(C=C1)OCCN(CC)CC)NC(C2=CC=CC=C2)=O)N(CCC)CCC
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Synonyms
CR 605
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Vidal y Plana RR, et al. Mechanism of smooth muscle relaxation by tiropramide. J Pharm Pharmacol. 1981;33(1):19-24. [Content Brief]
[2]. Soo Kyoung Baek, et al. Semi-micro high-performance liquid chromatographic analysis of tiropramide in human plasma using column-switching. J Pharm Biomed Anal. 2003 Feb 5;31(1):185-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tiropramide Related Classifications
HY-116755 Related Classifications
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