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Xirestomig

(Synonyms: ATG-101)
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Xirestomig (ATG-101) is a tetravalent "2+2″ PD-L1×4-1BB bispecific antibody. Xirestomig binds PD-L1 and 4-1BB concurrently, with a greater affinity for PD-L1, and potently activated 4-1BB+ T cells when cross-linked with PD-L1-positive cells. Xirestomig activates exhausted T cells upon PD-L1 binding. Xirestomig displays potent antitumor activity in numerous in vivo tumor models, including those resistant or refractory to immune checkpoint inhibitors (ICIs).

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  • Pureté: 98.44%
  • CAS No.: 2756879-35-1
  • Masse moléculaire:196.508 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Xirestomig
  • Experimental Validation Results for Xirestomig
  • Experimental Validation Results for Xirestomig
  • Xirestomig Chemical Structure
    Xirestomig Chemical Structure
CAS No.: 2756879-35-1
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Xirestomig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-lambda-[scFv]2-heavy-lambda

  • 1/16

    Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Xirestomig. The EC50 for this effect is 51.02 ng/mL.

  • 1/16

    Immobilized 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) can bind Xirestomig. The EC50 for this effect is 56.02 ng/mL.

  • Xirestomig Chemical Structure
    1/16
  • Xirestomig
  • Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Xirestomig. The EC50 for this effect is 51.02 ng/mL.
  • Immobilized 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) can bind Xirestomig. The EC50 for this effect is 56.02 ng/mL.
  • IgG1-lambda-[scFv]2-heavy-lambda