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Cat. No.: HY-162794

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YCH3124

YCH3124 (compound Z33) is a USP7 inhibitor (IC₅₀=41.9 nM) with antitumor activity. YCH3124 has good in vitro antiproliferative activity against various tumor cells including LNCaP (IC₅₀=3.6 nM) and CHP-212 (IC₅₀=9.9 nM). In addition, YCH3124 disrupts cell cycle progression by restricting G1 phase and induces apoptosis in CHP-212 cells.

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Formule: C₃₀H₃₄N₄O₅
Masse moléculaire:530.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

YCH3124 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

USP7

41.9 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Deubiquitinase :

Cellular Effect

Cell Line	Type	Value	Description	References
CHP-212	IC₅₀	>10000 nM Compound: Z33; YCH3124	Antiproliferative activity against human CHP-212 cells transfected with p53 siRNA assessed as reduction in cell viability incubated for 5 days by SRB assay Antiproliferative activity against human CHP-212 cells transfected with p53 siRNA assessed as reduction in cell viability incubated for 5 days by SRB assay	[PMID: 39133975]
CHP-212	IC₅₀	19.88 nM Compound: Z33; YCH3124	Antiproliferative activity against human CHP-212 cells transfected with p21 siRNA assessed as reduction in cell viability incubated for 5 days by SRB assay Antiproliferative activity against human CHP-212 cells transfected with p21 siRNA assessed as reduction in cell viability incubated for 5 days by SRB assay	[PMID: 39133975]
CHP-212	IC₅₀	9.9 nM Compound: Z33; YCH3124	Antiproliferative activity against human CHP-212 cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by SRB assay Antiproliferative activity against human CHP-212 cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by SRB assay	[PMID: 39133975]
LNCaP	IC₅₀	40.3 nM Compound: Z33; YCH3124	Antiproliferative activity against human LNCaP cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay Antiproliferative activity against human LNCaP cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay	[PMID: 39133975]
MM1.S	IC₅₀	10.7 nM Compound: Z33; YCH3124	Antiproliferative activity against human MM1.S cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days Antiproliferative activity against human MM1.S cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days	[PMID: 39133975]
MV4-11	IC₅₀	52.3 nM Compound: Z33; YCH3124	Antiproliferative activity against human MV4-11 cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay Antiproliferative activity against human MV4-11 cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay	[PMID: 39133975]

Chemical Information

Masse moléculaire 530.61
Formule C₃₀H₃₄N₄O₅
SMILES

O=C1N(CC2(O)CCN(C(C[C@@H](C)C3=CC=CC=C3)=O)CC2)C=NC4=C1C=CN4C5=CC=C(OC)C(OC)=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhen Zhuang, et al. "Discovery of pyrrolo [2, 3-d] pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy." European Journal of Medicinal Chemistry (2024): 116752. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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