CGS 18320B 

CGS 18320B is a human placental microsomal aromatase inhibitor with a K_i of 0.16 nM. CGS 18320B interacts reversibly with the enzyme's active site to block estrogen biosynthesis from androstenedione. CGS 18320B can be used for the research of aromatase inhibition and estrogen biosynthesis regulation^[1].

CGS 18320B (0.15 nM, 0.4 nM, 1.0 nM; 2 min preincubation, 5 min reaction) competitively inhibits human placental microsomal aromatase with an apparent K_i of 0.16 nM^[1].
CGS 18320B (0.17 nM, 0.5 nM, 1.7 nM, 8.4 nM; 0, 10, 20, 30 min preincubation, 10 min substrate incubation) reversibly inhibits human placental microsomal aromatase, with no time-dependent increase in inhibitory effect observed over 30 minutes of preincubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

402.40

C₂₂H₁₈N₄O₄

112808-99-8

N#CC1=CC=C(C(N2C=NC=C2)C3=CC=C(C=C3)C#N)C=C1.O=C(CCC(O)=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bullion KA, et al. Reversible inhibition of human placental microsomal aromatase by CGS 18320B and other non-steroidal compounds. Endocr Res. 1990;16(2):255-67.