CGS 18320B
CGS 18320B is a human placental microsomal aromatase inhibitor with a Ki of 0.16 nM. CGS 18320B interacts reversibly with the enzyme's active site to block estrogen biosynthesis from androstenedione. CGS 18320B can be used for the research of aromatase inhibition and estrogen biosynthesis regulation.
For research use only. We do not sell to patients.
- CAS No.: 112808-99-8
- Formula: C22H18N4O4
- Molecular Weight:402.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Aromatase 0.16 nM (Ki) |
CGS 18320B (0.15 nM, 0.4 nM, 1.0 nM; 2 min preincubation, 5 min reaction) competitively inhibits human placental microsomal aromatase with an apparent Ki of 0.16 nM[1].
CGS 18320B (0.17 nM, 0.5 nM, 1.7 nM, 8.4 nM; 0, 10, 20, 30 min preincubation, 10 min substrate incubation) reversibly inhibits human placental microsomal aromatase, with no time-dependent increase in inhibitory effect observed over 30 minutes of preincubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 112808-99-8
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Molecular Weight 402.40
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Formula C22H18N4O4
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SMILES
N#CC1=CC=C(C(N2C=NC=C2)C3=CC=C(C=C3)C#N)C=C1.O=C(CCC(O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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