5-POHSA
5-POHSA is a CD36 and Src kinase modulator acting on taste bud cells, and belongs to the fatty acid esters of hydroxy fatty acids (FAHFA) family. 5-POHSA binds to lingual CD36 to initiate intracellular signaling pathways, activate downstream Src kinase, and rapidly elevate intracellular calcium levels. 5-POHSA interacts with the tongue-brain axis by binding to CD36, so as to ameliorate taste disorders and obesity-related adverse reactions. 5-POHSA is applicable to the research of obesity.
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- CAS. Nr.: 2161370-68-7
- Formel: C34H64O4
- Molecular Weight:536.87
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
5-POHSA (5-100 μM; 5 min) activates Src kinase in cultured mouse taste bud cells in a concentration-dependent manner[1].
5-POHSA (20 μM) significantly increases calcium influx in mouse taste bud cells cultured in vitro via a CD36-dependent mechanism; in mock-transfected cells, its combined use with Linoleic acid (HY-N0729) produces a synergistic effect on calcium signals, while this response is attenuated in CD36 siRNA-transfected cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2161370-68-7
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Molecular Weight 536.87
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Formel C34H64O4
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SMILES
CCCCCCCCCCCCCC(OC(CCCCCCC/C=C\CCCCCC)=O)CCCC(O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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