Lysipressin
Based on 2 publication(s) in Google Scholar
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs. Lysipressin activates Oxytocin receptors and adenylate-cyclase. Lysipressin adjusts blood pressure and heart rate. Lysipressin shows antinociceptive activity.
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- Reinheit: 99.22%
- CAS. Nr.: 50-57-7
- Formel: C46H65N13O12S2
- Molecular Weight:1056.22
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Lysipressin
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Biologische Aktivität
Lysipressin (1 nM-1 μM) increases porcine myometrial [Ca2+]i and contractility predominantly by activating oxytocin receptors[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Lysipressin (0.1-100 mu/kg, i.v.) increases blood pressure and decreases heart rate in dogs[5].
lysine-vasopressin (0.01-10 mu/kg, intracisternal) induces a dose-related decrease in blood pressure and does not change heart rate in dogs[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 50-57-7
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Appearance Solid
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Molecular Weight 1056.22
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Formel C46H65N13O12S2
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Color White to off-white
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Synonyms
Lysine vasopressin; [Lys8]-Vasopressin
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Sequence
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
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Sequence Shortening
CYFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)
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Structure Classification
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Initial Source
pig
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
H2O : ≥ 100 mg/mL (94.68 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Gorbulev V et al. Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line. Eur J Biochem. 1993 Jul 1;215(1):1-7. [Content Brief]
[2]. Crankshaw D et al. [Arg8]vasopressin-induced contractions of rabbit urinary bladder smooth muscle.Eur J Pharmacol. 1989 Dec 7;173(2-3):183-8. [Content Brief]
[3]. Yu H, et al. Lysine vasopressin-induced increases in porcine myometrial contractility and intracellular Ca2+ concentrations of myometrial cells: involvement of oxytocin receptors. Biol Reprod. 1995 Mar;52(3):584-590. [Content Brief]
[4]. Kordower JH, et al. Central antinociceptive effects of lysine-vasopressin and an analogue. Peptides. 1982 Jul-Aug;3(4):613-7. [Content Brief]
[5]. Tran LD, et al. Effects of lysine-vasopressin and oxytocin on central cardiovascular control. Br J Pharmacol. 1982 Sep;77(1):69-73. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9468 mL | 4.7339 mL | 9.4677 mL | 23.6693 mL |
| 5 mM | 0.1894 mL | 0.9468 mL | 1.8935 mL | 4.7339 mL | |
| 10 mM | 0.0947 mL | 0.4734 mL | 0.9468 mL | 2.3669 mL | |
| 15 mM | 0.0631 mL | 0.3156 mL | 0.6312 mL | 1.5780 mL | |
| 20 mM | 0.0473 mL | 0.2367 mL | 0.4734 mL | 1.1835 mL | |
| 25 mM | 0.0379 mL | 0.1894 mL | 0.3787 mL | 0.9468 mL | |
| 30 mM | 0.0316 mL | 0.1578 mL | 0.3156 mL | 0.7890 mL | |
| 40 mM | 0.0237 mL | 0.1183 mL | 0.2367 mL | 0.5917 mL | |
| 50 mM | 0.0189 mL | 0.0947 mL | 0.1894 mL | 0.4734 mL | |
| 60 mM | 0.0158 mL | 0.0789 mL | 0.1578 mL | 0.3945 mL | |
| 80 mM | 0.0118 mL | 0.0592 mL | 0.1183 mL | 0.2959 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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