MTEP hydrochloride
Based on 3 publication(s) in Google Scholar
MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.79%
- CAS. Nr.: 1186195-60-7
- Formel: C11H9ClN2S
- Molecular Weight:236.72
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) MTEP hydrochloride
More
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
mGluR5 5 nM (IC50) |
mGluR5 16 nM (Ki) |
In Vitro
In Vivo
MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (215-315 g, 5-9/group)[2]
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Dosage:1, 3 and 5 mg/kg
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Administration:IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)
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Result:Inhibited the catalepsy induced by Haloperidol (HY-14538).
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Animal Model:Male C57BL/6J mice (23-25 g)[3]
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Dosage:0.3, 1 and 3 mg/kg
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Administration:IP, 1 h before the test
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Result:Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard.
Chemical Information
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CAS. Nr. 1186195-60-7
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Appearance Solid
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Molecular Weight 236.72
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Formel C11H9ClN2S
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Color Light yellow to yellow
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SMILES
CC1=NC(C#CC2=CC=CN=C2)=CS1.[H]Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Sci Adv
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission. [Abstract]2022 Aug 19;8(33):eabn7357. PMID: 35984881 -
Neurochem Int
Red nucleus mGluR1 and mGluR5 facilitate the development of neuropathic pain through stimulating the expressions of TNF-α and IL-1β. [Abstract]2024 Sep:178:105786. PMID: 38843952 -
Psychopharmacology (Berl)
2024 Jul;241(7):1399-1415. PMID: 38459971
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 20 mg/mL (84.49 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (422.44 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Lea PM 4th, et al. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006 Summer;12(2):149-66. [Content Brief]
[2]. Ossowska K, et al. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology. 2005 Sep;49(4):447-55. [Content Brief]
[3]. Pałucha A, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005 Aug;81(4):901-6. [Content Brief]
[4]. Klodzinska A, et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. Neuropharmacology. 2004 Sep;47(3):342-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.2244 mL | 21.1220 mL | 42.2440 mL | 105.6100 mL |
| 5 mM | 0.8449 mL | 4.2244 mL | 8.4488 mL | 21.1220 mL | |
| 10 mM | 0.4224 mL | 2.1122 mL | 4.2244 mL | 10.5610 mL | |
| 15 mM | 0.2816 mL | 1.4081 mL | 2.8163 mL | 7.0407 mL | |
| 20 mM | 0.2112 mL | 1.0561 mL | 2.1122 mL | 5.2805 mL | |
| 25 mM | 0.1690 mL | 0.8449 mL | 1.6898 mL | 4.2244 mL | |
| 30 mM | 0.1408 mL | 0.7041 mL | 1.4081 mL | 3.5203 mL | |
| 40 mM | 0.1056 mL | 0.5281 mL | 1.0561 mL | 2.6403 mL | |
| 50 mM | 0.0845 mL | 0.4224 mL | 0.8449 mL | 2.1122 mL | |
| 60 mM | 0.0704 mL | 0.3520 mL | 0.7041 mL | 1.7602 mL | |
| 80 mM | 0.0528 mL | 0.2640 mL | 0.5281 mL | 1.3201 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MTEP hydrochloride Related Classifications
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