Art. -Nr.: HY-B1779

Sucrose

(Synonyms: D-(+)-Saccharose)

12 Cited Publications

Kundenbewertung

Based on 12 publication(s) in Google Scholar

Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.

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Reinheit: 99.92%
CAS. Nr.: 57-50-1
Formel: C₁₂H₂₂O₁₁
Molecular Weight:342.30

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Sucrose Chemical Structure

CAS. Nr.: 57-50-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
- Clinical Trial
Chemical Information
Publications (12)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>30 μM Compound: 8	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 25466198]
BV-2	IC₅₀	>200 μM Compound: 8	Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay	[PMID: 25466198]
HCT-15	IC₅₀	>30 μM Compound: 8	Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 25466198]
SK-MEL-2	IC₅₀	>30 μM Compound: 8	Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 25466198]
SK-OV-3	IC₅₀	>30 μM Compound: 8	Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 25466198]

In Vivo

Sucrose is a disaccharide which is composed of two monosaccharides, glucose and fructose. Compare to chow-feeding, high-energy (HE)-feeding results in an overall decreased preference for Sucrose solutions in both strains. Specifically, obesity-prone (OP) rats prefer 0.3 M and 1.0 M Sucrose solutions less during HE-feeding relative to chow-feeding (P=0.046 and P=0.012, respectively). As well, obesity-resistant (OR) rats exhibit decreased preferences for 0.01 M, 0.03 M, and 1.0 M Sucrose when HE-fed compare to chow-fed counterparts (P<0.0001, P=0.043, and P=0.013, respectively). Chow-fed OP rats consume significantly less of 0.03 and 0.1 M Sucrose solutions relative to OR animals (P<0.0001, for both) while HE-fed OP rats consume less of a 0.1 M Sucrose solution only (P<0.05), compare to HE-fed OR rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 57-50-1
Appearance Solid
Molecular Weight 342.30
Formel C₁₂H₂₂O₁₁
Color White to off-white
SMILES

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@]2(CO)[C@@H](O)[C@H](O)[C@@H](CO)O2
Synonyms

D-(+)-Saccharose
Structure Classification
- Saccharides
- Polysaccharides
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (12)

All Cell Imaging/StainingBio/Physico-chemical AssayWB

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Journal Impact Factor

Signal Transduct Target Ther

Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer. [Abstract]

2025 Nov 18;10(1):373. PMID: 41249116
Nat Nanotechnol

Targeted protein degradation via cellular trafficking of nanoparticles. [Abstract]

2025 Feb;20(2):296-302. PMID: 39468359

Sucrose purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2025 Feb;20(2):296-302. [Abstract]

EGFR degradation in MDA-MB-231 cells after incubation with 500 nM NTZ-NPs and 75 mM Sucrose for 24 h.
Autophagy

The Valsa mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple. [Abstract]

2023 Jun;19(6):1745-1763. PMID: 36449354
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Food Chem

Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]

2023 Mar 30;405(Pt A):134807. PMID: 36370576
Front Immunol

Mannose Receptor Mediates the Activation of Chitooligosaccharides on Blunt Snout Bream ( Megalobrama amblycephala) Macrophages. [Abstract]

2021 Aug 2;12:686846. PMID: 34408745
Int Immunopharmacol

2026 Aug 15:183:116862. PMID: 42150287
iScience

2026 Jun 1;29(6):116200. PMID: 42256278
Vaccines

Preparation and Efficacy Evaluation of Heat-Resistant Freeze-Dried Live-Attenuated Vaccine Formulation of Micropterus salmoides Rhabdovirus. [Abstract]

2026 Jan 21;14(1):106. PMID: 41601021

Sucrose purchased from MedChemExpress. Usage Cited in: Vaccines. 2026 Jan 21;14(1):106. [Abstract]

Pretreat cells with endocytosis inhibitors (Sucrose; 300 mM; 2 h) or absence (control) and observe the uptake of fluorescein isothiocyanate (FITC)-COS6 by macrophages under a confocal microscope. The co-localization percentage of FITC-COS6 and nucleus was analyzed using WCIF ImageJ software.

Sucrose purchased from MedChemExpress. Usage Cited in: Vaccines. 2026 Jan 21;14(1):106. [Abstract]

Cells were treated with endocytosis inhibitors (Sucrose; 300 mM) and incubated with FITC-labeled COS6, washed, lysed, and mixed uniformly. Fluorescence intensity was measured.
Mol Biotechnol

Inhibition of γδ T Cells Alleviates Blood-Brain Barrier in Cardiac Arrest and Cardiopulmonary Resuscitation in Mice. [Abstract]

2023 Dec;65(12):2061-2070. PMID: 36944895
J Vis Exp

Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation. [Abstract]

2025 Jun 17:(220). PMID: 40622958
SSRN

2026 Mar 3.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (292.14 mM; Need ultrasonic and warming)

DMSO : 100 mg/mL (292.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9214 mL

14.6071 mL

29.2141 mL

5 mM

0.5843 mL

2.9214 mL

5.8428 mL

10 mM

0.2921 mL

1.4607 mL

2.9214 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (292.14 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Protokoll

Animal Administration^[1]

A total of 66 male 8-wk-old Sprague-Dawley obesity-prone (OP) and obesity-resistant (OR) rats (n = 38 per each phenotype), weighing 275 g and 210 g respectively, are used in this study. After recovery and attaining pre-surgical weights, rats undergo three training trials of 60-min sham feeding sessions with 0.03 M Sucrose solution. During testing, rats are briefly deprived of water (0900 to 1600 h) but not food, and are tested for 1 h (1400 to1500 h) sham intake of 0.03 M Sucrose solution until a stable baseline is achieved. Afterwards, rats are sham fed one of three Sucrose solutions (0.03, 0.3, and 1.0 M) in random order, every other day, with each concentration tested at least twice. Sucrose intake is individually recorded every 5 min for 60 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Duca FA, et al. Effect of diet on preference and intake of sucrose in obese prone and resistant rats. PLoS One. 2014 Oct 20;9(10):e111232. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.9214 mL	14.6071 mL	29.2141 mL	73.0354 mL
	5 mM	0.5843 mL	2.9214 mL	5.8428 mL	14.6071 mL
	10 mM	0.2921 mL	1.4607 mL	2.9214 mL	7.3035 mL
	15 mM	0.1948 mL	0.9738 mL	1.9476 mL	4.8690 mL
	20 mM	0.1461 mL	0.7304 mL	1.4607 mL	3.6518 mL
	25 mM	0.1169 mL	0.5843 mL	1.1686 mL	2.9214 mL
	30 mM	0.0974 mL	0.4869 mL	0.9738 mL	2.4345 mL
	40 mM	0.0730 mL	0.3652 mL	0.7304 mL	1.8259 mL
	50 mM	0.0584 mL	0.2921 mL	0.5843 mL	1.4607 mL
	60 mM	0.0487 mL	0.2435 mL	0.4869 mL	1.2173 mL
	80 mM	0.0365 mL	0.1826 mL	0.3652 mL	0.9129 mL
	100 mM	0.0292 mL	0.1461 mL	0.2921 mL	0.7304 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Sucrose

12 Cited Publications

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Sucrose

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

Cosmetic Ingredient Compound Library

Publications Citing Use of MedChemExpress (MCE) Sucrose

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (12)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Sucrose

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

Cosmetic Ingredient Compound Library

Publications Citing Use of MedChemExpress (MCE) Sucrose

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (12)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Sucrose Related Classifications

HY-B1779 Related Classifications