Furin
Furin
Furin belongs to the proprotein convertase (PC) family. Furin is able to recognize specific amino acid sequences and cleave the protein precursors at these sequences, thereby converting inactive precursor proteins into mature proteins with functional activity. Furin is involved in the processing and maturation of intracellular proteins, such as coagulation factor Ⅷ and angiotensinogen. By cleaving cell surface receptors and signaling molecules, Furin participates in cell signaling transduction and regulates various vital activities of cells, such as cell proliferation, differentiation, and apoptosis. In addition, during viral infections, Furin can cleave the glycoproteins on the surface of the virus, promoting the fusion of the virus with the host cell membrane and facilitating the entry of the virus into the host cell. Furin plays an important role in a variety of diseases, including cardiovascular diseases, tumors, neurodegenerative diseases, and infectious diseases[1][2].
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Furin Verwandte Produkte (11)
Verwandte Produkte (11)
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Antibodies (2)
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DEC-RVRK-CMK TFA
0 ImagesArt. -Nr.: HY-P5062AReinheit: 99.04%Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFADEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position.
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SSM3 tetraTFA hydrate
0 ImagesArt. -Nr.: HY-110147BReinheit: 99.9%SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.
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DEC-RVRK-CMK
0 ImagesArt. -Nr.: HY-P5062CAS. Nr.: 534615-50-4Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketoneDEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position.
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PAI-1-IN-1
0 ImagesPAI-1-IN-1 is an orally active and specific PAI-1 inhibitor with an IC50 of <6.95 μM. PAI-1-IN-1 blocks the interaction between PAI-1 and serine proteases or LRP-1, and enhances plasmin generation. PAI-1-IN-1 restores macrophage efferocytosis and promotes macrophage polarization. PAI-1-IN-1 alleviates PAI-1-mediated inhibition of Furin, promotes MT1-MMP maturation, activates the NOTCH1 signaling pathway, inhibits proliferation and induces apoptosis. PAI-1-IN-1 promotes skeletal muscle regeneration and alleviates inflammation in a mouse model of skeletal muscle injury. PAI-1-IN-1 can be used in research on skeletal muscle injury-induced inflammation and chronic myeloid leukemia.
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PAI-1
0 ImagesArt. -Nr.: HY-P11413CAS. Nr.: 139446-70-1PAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus.
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SSM3 tetraTFA
0 ImagesArt. -Nr.: HY-110147ACAS. Nr.: 2320930-10-5SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.
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Furin-IN-3
0 ImagesArt. -Nr.: HY-180145CAS. Nr.: 3080672-14-3
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Furin Substrate
0 ImagesArt. -Nr.: HY-P3797CAS. Nr.: 174838-79-0
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