Art. -Nr.: HY-N1501

Beta-asarone

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Beta-asarone is an orally active and BBB-penetrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, inhibit expression of α-synuclein, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases.

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Reinheit: 99.94%
CAS. Nr.: 5273-86-9
Formel: C₁₂H₁₆O₃
Molecular Weight:208.25

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Beta-asarone Chemical Structure

CAS. Nr.: 5273-86-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

α-synuclein

Alle α-synuclein Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	126.11 μM Compound: A, beta-Asarone	Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23395966]
MCF7	IC₅₀	129.35 μM Compound: A, beta-Asarone	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23395966]
Oocyte	EC₅₀	171.5 μM Compound: 1	Allosteric modulation of rat gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current after 20 secs by voltage clamp assay Allosteric modulation of rat gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current after 20 secs by voltage clamp assay	[PMID: 21563811]
SW982	IC₅₀	>150 μM Compound: A, beta-Asarone	Cytotoxicity against human SW982 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SW982 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23395966]

In Vitro

Beta-asarone (7.5-30 μg/mL; 25 h) can protect PC12 cells against Aβ_1-42 induced cytotoxicity and autophagy^[1].
Beta-asarone (100 μM; 2 h) inhibits the up-regulation of MALAT1 and α-synuclein expression in SH-SY5Y cells treated with MPP+ (HY-W008719)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[2]

Cell Line:

MPP+ (HY-W008719) treated SH-SY5Y cells
Concentration:

100 μM
Incubation Time:

2 h
Result:

Down-regulated the mRNA levels of MALAT1 and α-synuclein.

In Vivo

Beta-asarone (intragastric administration; 10 mg/kg; 28 days) exhibits a neuroprotective effect in a mouse model of Parkinson's disease^[2].
Beta-asarone (oral administration; 12.5-50 mg/kg; 28 days) alleviates Aβ_1–42-induced apoptosis of hippocampal neurons in a rat model of Alzheimer's disease^[3].
Beta-asarone (intraperitoneal injection; 10-30 mg/kg; single dose) has anti-inflammatory and protective effects in a rat model of myocardial ischemia-reperfusion^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MPTP (HY-15608) treated male C57BL/6 mice aged 9-10 weeks old^[2]
Dosage:

10 mg/kg
Administration:

Intragastric administration; 28 days
Result:

Markedly increased the TH+ cells of MPTP induced PD mouse.
Down-regulated the expression levels of MALAT1 and α-synuclein in midbrain.
Increased the expression levels of Bcl-2.

Animal Model:

Ischemic-reperfusion treated male Sprague-Dawley rats (240-280g)^[4]
Dosage:

10, 20 and 30 mg/kg
Administration:

Intraperitoneal injection (i.p.); single dose
Result:

Significantly improved the heart outcome after myocardial ischemia and reperfusion in terms of less infarction size and lower serum cTNT concentration.
Evidently inhibited inflammatory response with less granulocyte infiltration, mild tissue edema and lower tissue MPO content.
Suppressed NLRP3 signal pathway and cardiac cell’s pyroptosis for less protein expressions of ASC and NLRP3, lower level cleavage activation of caspase-1and GSDMSD, and lower serum IL-1β concentration.
Well preserved the left ventricular performance with higher ejection fraction and fractional shortening.

Chemical Information

CAS. Nr. 5273-86-9
Appearance Liquid (Density: 1.073 g/cm³)
Molecular Weight 208.25
Formel C₁₂H₁₆O₃
Color Colorless to light yellow
SMILES

C/C=C\C1=C(OC)C=C(OC)C(OC)=C1
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

All Cell Proliferation/Viability AssayWB

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Journal Impact Factor

Eur J Pharmacol

Beta-asarone alleviated cerebral ischemia/reperfusion injury by targeting PINK1/Parkin-dependent mitophagy. [Abstract]

2025 Sep 5:1002:177831. PMID: 40490171
Cancer Med

β-asarone inhibits the migration, invasion, and EMT of bladder cancer through activating ER stress. [Abstract]

2023 Jun;12(12):13610-13622. PMID: 37306628
Biochem Genet

β-Asarone Inhibits Carboplatin Resistance in Retinoblastoma Cells Through the UCA1/miR-206/NRP1 Axis. [Abstract]

2024 Dec 24. PMID: 39718722
Int Ophthalmol

β-asarone attenuates the proliferation, migration and enhances apoptosis of retinoblastoma through Wnt/β-catenin signaling pathway. [Abstract]

2023 May;43(5):1687-1699. PMID: 36372820

Beta-asarone purchased from MedChemExpress. Usage Cited in: Int Ophthalmol. 2023 May;43(5):1687-1699. [Abstract]

Beta-asarone (β-asarone; 100 μM; 24 h) signifcantly reduces the proliferation of RB cells.

Beta-asarone purchased from MedChemExpress. Usage Cited in: Int Ophthalmol. 2023 May;43(5):1687-1699. [Abstract]

Beta-asarone (β-asarone; 100 μM; 4 h) facilitates the apoptosis of RB cells.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (480.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.8019 mL

24.0096 mL

48.0192 mL

5 mM

0.9604 mL

4.8019 mL

9.6038 mL

10 mM

0.4802 mL

2.4010 mL

4.8019 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.75 mg/mL (13.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.75 mg/mL (13.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.75 mg/mL (13.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xue Z, et al. Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells. Eur J Pharmacol. 2014 Oct 15;741:195-204. [Content Brief]

[2]. Zhang QS, et al. Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression. Biomed Pharmacother. 2016 Oct;83:153-159. [Content Brief]

[3]. Liu J, et al. Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus. Yakugaku Zasshi. 2010 May;130(5):737-46. [Content Brief]

[4]. Xiao B, et al. Beta-Asarone Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis. Biol Pharm Bull. 2020 Jul 1;43(7):1046-1051. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.8019 mL	24.0096 mL	48.0192 mL	120.0480 mL
	5 mM	0.9604 mL	4.8019 mL	9.6038 mL	24.0096 mL
	10 mM	0.4802 mL	2.4010 mL	4.8019 mL	12.0048 mL
	15 mM	0.3201 mL	1.6006 mL	3.2013 mL	8.0032 mL
	20 mM	0.2401 mL	1.2005 mL	2.4010 mL	6.0024 mL
	25 mM	0.1921 mL	0.9604 mL	1.9208 mL	4.8019 mL
	30 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0016 mL
	40 mM	0.1200 mL	0.6002 mL	1.2005 mL	3.0012 mL
	50 mM	0.0960 mL	0.4802 mL	0.9604 mL	2.4010 mL
	60 mM	0.0800 mL	0.4002 mL	0.8003 mL	2.0008 mL
	80 mM	0.0600 mL	0.3001 mL	0.6002 mL	1.5006 mL
	100 mM	0.0480 mL	0.2401 mL	0.4802 mL	1.2005 mL

Keywords

Beta-asarone

4 Cited Publications

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Beta-asarone

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Publications Citing Use of MedChemExpress (MCE) Beta-asarone

Alle α-synuclein Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Beta-asarone Related Classifications

HY-N1501 Related Classifications