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Art. -Nr.: HY-171925

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BI-1124

BI-1124 is a cathepsin S inhibitor that exhibits simulated sufficient ocular pharmacokinetic-pharmacodynamic coverage in rabbit models via topical ocular administration. BI-1124 can be used for the research of age-related dry eye disease.

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CAS. Nr.: 752237-69-7
Formel: C₂₂H₃₉N₅O₃
Molecular Weight:421.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

BI-1124 Chemical Structure

CAS. Nr.: 752237-69-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

cathepsin S

Alle Cathepsin Isoform-spezifische Produkte anzeigen :

In Vitro

BI-1124 (0.075 mg/mL, 0.0075% w/v) exhibits high corneal permeability, sufficient solubility, and a suitable partition coefficient at pH 7.4 in in silico ADMET and ocular pharmacokinetic analyses. After simulated topical administration, its concentrations in rabbit cornea and conjunctiva can remain sustained above the in vitro IC₅₀ (7 nM) and IC₉₀ (70 nM) levels, which supports its potential to be repurposed for age-related dry eye disease through the inhibition of cathepsin S^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 752237-69-7
Molecular Weight 421.59
Formel C₂₂H₃₉N₅O₃
SMILES

N(C([C@@H](NC(=O)N1CCOCC1)CCC(C)(C)C)=O)C2(C#N)CCN(CCC)CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Baltazar B, et al. In silico simulation models for preclinical pharmacokinetic profiling in drug repositioning of a cathepsin S inhibitor for age-related dry eye. Investigative Ophthalmology & Visual Science. 2024 Jun 17;65(7):6124-.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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BI-1124

Alle Cathepsin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BI-1124 Related Classifications

HY-171925 Related Classifications