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Art. -Nr.: HY-136881

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CH0076989

CH0076989 is a specific CCR3 agonist. CH0076989 activates eosinophils and transfectants expressing both wild-type CCR3 and a CCR1:CCR3 chimaeric receptor lacking the CCR3 amino-terminus. CH0076989 has a direct interaction with the transmembrane helices of CCR3, supported by the complete loss of its activity due to mutations of the residues Y41, Y113 and E287. CH0076989 can be used for the study of inflammation and allergic diseases (such as asthma).

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CAS. Nr.: 954371-52-9
Formel: C₂₄H₂₂Br₂N₂O₂
Molecular Weight:530.25

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CH0076989 Chemical Structure

CAS. Nr.: 954371-52-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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Biologische Aktivität

Beschreibung

Alle CCR Isoform-spezifische Produkte anzeigen :

In Vitro

CH0076989 (0.01-10 μM, 4 min) induces eosinophil shape change in a dose dependent manner^[1].
CH0076989 (0.0001-10 μM, 5 h) elicits chemotaxis in CCR3-transfected L1.2 cells with an optimal concentration of 1 μM, but has no effect on CCR1-transfected cells^[1].
CH0076989 (10 μM, 20 min) induces CCR3 internalization in CCR3-transfected L1.2 cells, which is dose-dependently inhibited by cis-J-113863 (UCB35625) (HY-103360A)^[1].
CH0076989 (0.0001-10 μM, 5 h) induces chemotaxis in L1.2 cells transfected with the CCR1:CCR3 chimeric receptor (Chi-1)^[1].
CH0076989 (0.0001-10 μM, 5 h) fails to induce chemotaxis in L1.2 cells transfected with Y41A, Y113A, or E287Q mutant CCR3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 954371-52-9
Molecular Weight 530.25
Formel C₂₄H₂₂Br₂N₂O₂
SMILES

BrC1=CC(NC(CC2=C3C=COC3=CC=C2)=O)=CC=[N+]1CCCC4=CC=CC=C4.[Br-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wise EL, et al. Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation. J Biol Chem. 2007 Sep 21;282(38):27935-43. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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CH0076989

Alle CCR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

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CH0076989 Related Classifications

HY-136881 Related Classifications