CSLP43
CSLP43 is a selective RIPK2 and XIAP inhibitor with an IC50 of 19.9 nM against human RIPK2. CSLP43 binds to the ATP-binding pocket of RIPK2 and disrupts the interaction between RIPK2 and the BIR2 domain of XIAP or cIAP1. CSLP43 inhibits RIPK2 ubiquitination, NOD1-dependent inflammatory signaling pathways, NOD2-dependent inflammatory signaling pathways, as well as NF-κB activation associated with NOD agonists. CSLP43 is selective for the NOD1/NOD2 signaling pathway and does not inhibit the kinase activity of RIPK1 or RIPK3. CSLP43 is applicable to research related to Crohn's disease, Blau syndrome, early-onset sarcoidosis and early-onset inflammatory bowel disease.
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- CAS. Nr.: 2244988-80-3
- Formel: C26H33N5O4S
- Molecular Weight:511.64
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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RIPK2 19.9 nM (IC50) |
XIAP |
NOD2 |
NOD1 |
CSLP43 inhibits NOD2-mediated NF-κB activation in HEKBlue hNOD2 cells with an IC50 of 1.3 nM[1].
CSLP43 binds to intracellular RIPK2 in HEKBlue cells, with an IC50 of 10.1 nM and a residence time of 106.9 min[1].
CSLP43 (0-1 μM; 4 h) inhibits L18-MDP (HY-148690)-induced CXCL8 production in U2OS/NOD2 cells[1].
CSLP43 inhibits MDP-induced TNF release in RAW264.7 macrophages with an IC50 of 1.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 mouse macrophages
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Concentration:serial dilutions
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Incubation Time:24 h (with MDP stimulation)
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Result:Inhibited MDP-induced TNF release with an IC50 of 1.2 nM.
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Cell Line:U2OS/NOD2 cell
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Concentration:0, 10, 50, 250, 1000 nM
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Incubation Time:4 h with L18-MDP stimulation
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Result:Dose-dependently inhibited L18-MDP-induced CXCL8 production in U2OS/NOD2 cells
Chemical Information
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CAS. Nr. 2244988-80-3
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Molecular Weight 511.64
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Formel C26H33N5O4S
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SMILES
O=S(=O)(NC=1C=C(C=C(OC)C1OC)C2=CC(=CN=C2N)C=3C=CC(=CC3)N4CCNCC4)CCC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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