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Art. -Nr.: HY-116065

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CUMI-101

CUMI-101 (compound 8) is a 5-HT_1AR agonist (K_i=0.15 nM) with an EC₅₀ of 0.1 nM in the [35S]GTPγS binding assay. CUMI-101 can be used in the research of neurological diseases.

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CAS. Nr.: 179756-61-7
Formel: C₁₉H₂₇N₅O₃
Molecular Weight:373.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CUMI-101 Chemical Structure

CAS. Nr.: 179756-61-7

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Biologische Aktivität
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- Cellular Effect
Chemical Information
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Biologische Aktivität

Beschreibung

CUMI-101 (compound 8) is a 5-HT_1AR agonist (K_i=0.15 nM) with an EC₅₀ of 0.1 nM in the [35S]GTPγS binding assay. CUMI-101 can be used in the research of neurological diseases^[1].

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.1 nM Compound: 8, CUMI-101	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	[PMID: 25182564]
CHO	EC₅₀	0.1 nM Compound: CUMI-101	Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding	[PMID: 23816046]

Chemical Information

CAS. Nr. 179756-61-7
Molecular Weight 373.45
Formel C₁₉H₂₇N₅O₃
SMILES

O=C(N(N=CC1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OC)N1C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kumar J S D, et al. Synthesis and evaluation of arylpiperazines derivatives of 3, 5-dioxo-(2H, 4H)-1, 2, 4-triazine as 5-HT1AR ligands[J]. Bioorganic & medicinal chemistry letters, 2014, 24(19): 4759-4762. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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CUMI-101

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CUMI-101 Related Classifications

HY-116065 Related Classifications