cyclo(CLLFVY)
Based on 1 Customer Validation
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers.
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- Reinheit: 99.37%
- CAS. Nr.: 1446322-73-1
- Formel: C38H54N6O7S
- Molecular Weight:738.94
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Chemical Information
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CAS. Nr. 1446322-73-1
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Appearance Solid
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Molecular Weight 738.94
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Formel C38H54N6O7S
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Color White to off-white
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Sequence
cyclo(Cys-Leu-Leu-Phe-Val-Tyr)
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Sequence Shortening
cyclo(CLLFVY)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (135.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3533 mL | 6.7664 mL | 13.5329 mL | 33.8322 mL |
| 5 mM | 0.2707 mL | 1.3533 mL | 2.7066 mL | 6.7664 mL | |
| 10 mM | 0.1353 mL | 0.6766 mL | 1.3533 mL | 3.3832 mL | |
| 15 mM | 0.0902 mL | 0.4511 mL | 0.9022 mL | 2.2555 mL | |
| 20 mM | 0.0677 mL | 0.3383 mL | 0.6766 mL | 1.6916 mL | |
| 25 mM | 0.0541 mL | 0.2707 mL | 0.5413 mL | 1.3533 mL | |
| 30 mM | 0.0451 mL | 0.2255 mL | 0.4511 mL | 1.1277 mL | |
| 40 mM | 0.0338 mL | 0.1692 mL | 0.3383 mL | 0.8458 mL | |
| 50 mM | 0.0271 mL | 0.1353 mL | 0.2707 mL | 0.6766 mL | |
| 60 mM | 0.0226 mL | 0.1128 mL | 0.2255 mL | 0.5639 mL | |
| 80 mM | 0.0169 mL | 0.0846 mL | 0.1692 mL | 0.4229 mL | |
| 100 mM | 0.0135 mL | 0.0677 mL | 0.1353 mL | 0.3383 mL |
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