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Art. -Nr.: HY-19501

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DPC-168

DPC-168 is an orally effective CCR3 antagonist (IC₅₀ = 41 nM). DPC-168 exhibits a significant ability to inhibit eosinophil chemotaxis and pulmonary inflammation. DPC-168 can be used for research on airway inflammation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 275810-55-4
Formel: C₂₈H₃₆FN₃O₂
Molecular Weight:465.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DPC-168 Chemical Structure

CAS. Nr.: 275810-55-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle CCR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	2 nM Compound: 1, DPC168	Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins	[PMID: 17418570]
CHO	IC₅₀	2 nM Compound: 2a	Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells	[PMID: 18096386]
CHO	IC₅₀	2 nM Compound: 32	Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells	[PMID: 15771462]
CHO	IC₅₀	54 nM Compound: 1, DPC168	Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins	[PMID: 17418570]

Chemical Information

CAS. Nr. 275810-55-4
Molecular Weight 465.60
Formel C₂₈H₃₆FN₃O₂
SMILES

O=C(N[C@H]1[C@H](CN2C[C@H](CC3=CC=C(F)C=C3)CCC2)CCCC1)NC4=CC=CC(C(C)=O)=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. D'Elios M M, et al. Interfering with chemokines and chemokine receptors as potential new therapeutic strategies[J]. Expert Opinion on Therapeutic Patents, 2008, 18(3): 309-325.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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