Eschweilenol C
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Eschweilenol C is a selective Plasmodium falciparum growth inhibitor. Eschweilenol C disrupts haemoglobin metabolism, reduces haemozoin production, kills Plasmodium falciparum ring and trophozoite stages. Eschweilenol C can be used for the research of inflammatory disorders and malaria.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 211371-02-7
- Formel: C20H16O12
- Molecular Weight:448.33
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Plasmodium |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
88 μg/mL
Compound: 2
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Cytotoxicity against mouse B16 cells after 3 days by MTT assay
Cytotoxicity against mouse B16 cells after 3 days by MTT assay
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[PMID: 12762821] |
| HeLa | IC50 |
86.5 μg/mL
Compound: 2
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Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
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[PMID: 12762821] |
| K562 | IC50 |
67 μg/mL
Compound: 2
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Cytotoxicity against adriamycin-resistant human K562 cells after 3 days by MTT assay
Cytotoxicity against adriamycin-resistant human K562 cells after 3 days by MTT assay
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[PMID: 12762821] |
| K562 | IC50 |
82 μg/mL
Compound: 2
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Cytotoxicity against human K562 cells after 3 days by MTT assay
Cytotoxicity against human K562 cells after 3 days by MTT assay
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[PMID: 12762821] |
| KB | IC50 |
98 μg/mL
Compound: 2
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Cytotoxicity against human KB cells after 3 days by MTT assay
Cytotoxicity against human KB cells after 3 days by MTT assay
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[PMID: 12762821] |
| P388 | IC50 |
53 μg/mL
Compound: 2
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Cytotoxicity against adriamycin-resistant mouse P388 cells after 3 days by MTT assay
Cytotoxicity against adriamycin-resistant mouse P388 cells after 3 days by MTT assay
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[PMID: 12762821] |
| P388 | IC50 |
62 μg/mL
Compound: 2
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Cytotoxicity against mouse P388 cells after 3 days by MTT assay
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
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[PMID: 12762821] |
In Vitro
Eschweilenol C (72 h) potently inhibits the growth of PfDd2, Pf3D7, and mutant-resistant PfDd2-GNF156 Plasmodium falciparum asexual blood stages with IC50 values ranging from 379.21 nM to 490.74 nM and a low resistance index of 1.29[2].
Eschweilenol C (1-5 μg/mL; 48 h) is inactive against late-stage IV/V Plasmodium falciparum NF54-E gametocytes, with an IC50 greater than 5 μg/mL[2].
Eschweilenol C is non-toxic to Vero, Raw 264.7, and O+ human red blood cells, with high selectivity indices (SI > 10) against Plasmodium falciparum asexual blood stages[2].
Eschweilenol C (72 h) significantly inhibits haemozoin production by Plasmodium falciparum at its PfDd2 IC50 concentration of 490.74 nM[2].
Eschweilenol C (24-72 h) acts slowly against Plasmodium falciparum PfDd2, with an IC50 of 557.66 nM at 48 h and no measurable IC50 at 24 h[2].
Eschweilenol C preferentially inhibits Plasmodium falciparum PfDd2 ring and trophozoite stages (82.13% and 85.01% growth inhibition, respectively) with a parasiticidal effect, and has weaker activity against schizonts (58.88% growth inhibition) with a parasitostatic effect[2].
Eschweilenol C displays strong binding affinity with Plasmodium falciparum PfM1AAP (-8.7 kcal/mol) and PfM17LAP (-8.3 kcal/mol)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 211371-02-7
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Appearance Solid
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Molecular Weight 448.33
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Formel C20H16O12
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Color White to off-white
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SMILES
OC(C1=C2C3=C(C(O)=C(C=C3C(O1)=O)O)O4)=C(O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)C=C2C4=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (223.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
[1]. Rodrigues de Araújo A, et al. Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart. J Ethnopharmacol. 2019;240:111941. [Content Brief]
[2]. Tali MBT, et al. Eschweilenol C and subfractions from Terminalia plants disrupt haemoglobin metabolism, inhibiting Plasmodium falciparum growth at rings and trophozoite stages. Malar J. 2025;24(1):422. Published 2025 Nov 24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2305 mL | 11.1525 mL | 22.3050 mL | 55.7625 mL |
| 5 mM | 0.4461 mL | 2.2305 mL | 4.4610 mL | 11.1525 mL | |
| 10 mM | 0.2230 mL | 1.1152 mL | 2.2305 mL | 5.5762 mL | |
| 15 mM | 0.1487 mL | 0.7435 mL | 1.4870 mL | 3.7175 mL | |
| 20 mM | 0.1115 mL | 0.5576 mL | 1.1152 mL | 2.7881 mL | |
| 25 mM | 0.0892 mL | 0.4461 mL | 0.8922 mL | 2.2305 mL | |
| 30 mM | 0.0743 mL | 0.3717 mL | 0.7435 mL | 1.8587 mL | |
| 40 mM | 0.0558 mL | 0.2788 mL | 0.5576 mL | 1.3941 mL | |
| 50 mM | 0.0446 mL | 0.2230 mL | 0.4461 mL | 1.1152 mL | |
| 60 mM | 0.0372 mL | 0.1859 mL | 0.3717 mL | 0.9294 mL | |
| 80 mM | 0.0279 mL | 0.1394 mL | 0.2788 mL | 0.6970 mL | |
| 100 mM | 0.0223 mL | 0.1115 mL | 0.2230 mL | 0.5576 mL |
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