Fosthiazate
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Fosthiazate is an inhibitor of acetylcholinesterase (Acetylcholinesterase, AChE). Fosthiazate exhibits significant nematicidal activity and systemic insecticidal activity. Fosthiazate is applicable to studies on plant-parasitic nematodes, root-knot diseases, agricultural pests, as well as the ecotoxicology and environmental behavior of organophosphorus compounds.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.11%
- CAS. Nr.: 98886-44-3
- Formel: C9H18NO3PS2
- Molecular Weight:283.35
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
Fosthiazate (both (+) and (-) isomers) exhibits weak inhibitory effects on acetylcholinesterase in the head of house flies, with an IC50 > 10-3 M[1].
The degradation half-life of fosthiazate (5 μg/g soil; 20 °C; up to 60 days) is 17.7-46.8 days in non-sterilized soil, while it is 28.4-87.7 days in sterilized soil, indicating that its degradation in soil involves both chemical and microbial processes[2].
Fosthiazate (2-25 μg/mL; 24 h) shows weak adsorption to San Emigdio sandy loam, Arlington sandy loam, and Waukegan silty clay loam, with its linear adsorption coefficient (Kd) ranging from 0.10 to 0.89[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Fosthiazate (2-20 mg/kg soil; 14 or 28 days) reduces AChE activity in Eisenia fetida in a dose-dependent manner and alters the expression of AChE-related genes[3].
Fosthiazate (7.9-31.6 mg/pot; applied to the root zone; 48 h after nematode inoculation) reduces the numbers of root galls, egg masses and nematode eggs in chili peppers infected by M. enterolobii, with the maximum reduction rates of 58.6%, 64.7% and 83.7% respectively observed in Trial 1[4]
Fosthiazate (3 kg a.i./ha; 2 applications; at transplanting and 3 months later) reduces root galls and egg counts by 39.8% and 80.1%, respectively, in the 'Super Hot' pepper cultivar, and by 59.6% and 67.5%, respectively, in the 'Amphawa Hot Pepper' cultivar, in natural root-knot nematode-infested pepper fields in Ubon Ratchathani[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3-week-old Super Hot chili; M. enterolobii KK1 or UB1; greenhouse[4]
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Dosage:7.9, 15.8, 23.7 or 31.6 mg/pot; 5 weeks
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Administration:Applied to root zone 24 h before inoculation with 1000 J2
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Result:Reduced galls by up to 98.7%, egg masses by up to 99.6%, and eggs by up to 100.0% in Trial 1.
Chemical Information
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CAS. Nr. 98886-44-3
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Appearance Liquid (Density: 1.268±0.10 g/cm3)
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Molecular Weight 283.35
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Formel C9H18NO3PS2
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Color Colorless to light yellow
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SMILES
CC(CC)SP(N1CCSC1=O)(OCC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 50 mg/mL (176.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (290 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5292 mL | 17.6460 mL | 35.2920 mL | 88.2301 mL |
| 5 mM | 0.7058 mL | 3.5292 mL | 7.0584 mL | 17.6460 mL | |
| 10 mM | 0.3529 mL | 1.7646 mL | 3.5292 mL | 8.8230 mL | |
| 15 mM | 0.2353 mL | 1.1764 mL | 2.3528 mL | 5.8820 mL | |
| 20 mM | 0.1765 mL | 0.8823 mL | 1.7646 mL | 4.4115 mL | |
| 25 mM | 0.1412 mL | 0.7058 mL | 1.4117 mL | 3.5292 mL | |
| 30 mM | 0.1176 mL | 0.5882 mL | 1.1764 mL | 2.9410 mL | |
| 40 mM | 0.0882 mL | 0.4412 mL | 0.8823 mL | 2.2058 mL | |
| 50 mM | 0.0706 mL | 0.3529 mL | 0.7058 mL | 1.7646 mL | |
| 60 mM | 0.0588 mL | 0.2941 mL | 0.5882 mL | 1.4705 mL | |
| 80 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1029 mL | |
| 100 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.8823 mL |
Fosthiazate Related Classifications
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