ANKRD28 - ankyrin repeat domain 28 Gene

Also Known as PITK; FAP79; CFAP79; PPP1R65

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23243

About ANKRD28

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:15,667,236-15,859,814 (from NCBI)

This gene has 16 transcripts (splice variants), 282 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 10.7) and 25 other tissues.

Summary

Predicted to be located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANKRD28 Products (12)

mRNA Protein Name
NM_001195098.1 NP_001182027.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b
NM_001195099.2 NP_001182028.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b
NM_001349277.2 NP_001336206.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform c
NM_001349278.2 NP_001336207.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform d
NM_001349279.2 NP_001336208.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform e
NM_001349280.1 NP_001336209.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f
NM_001349281.2 NP_001336210.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f
NM_001349282.2 NP_001336211.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f
NM_001349283.2 NP_001336212.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b
NM_001349284.2 NP_001336213.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform g
NM_001349285.2 NP_001336214.1 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform h
NM_015199.4 NP_056014.2 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
18186651 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANKRD28 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (12 - 104)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (108 - 170)

Ank

Ank: Ankyrin repeat (176 - 204)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (210 - 301)

Ank

Ank: Ankyrin repeat (338 - 365)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (376 - 467)

Ank

Ank: Ankyrin repeat (471 - 503)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (538 - 613)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (617 - 683)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (690 - 778)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (792 - 886)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (894 - 972)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1053 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

  • PP6-ARS-A

ANKRD28 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ANKRD28 O15084 KCNV2 Homo sapiens Q8TDN2
Validated Y2H
32296183
Intra
ANKRD28 O15084 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra
ANKRD28 O15084 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra
ANKRD28 O15084 PTRH1 Homo sapiens Q86Y79
Validated Y2H
32296183
Intra
ANKRD28 O15084 YTHDC1 Homo sapiens Q96MU7
Validated Y2H
32296183
Intra
ANKRD28 O15084 EIF3D Homo sapiens O15371
Validated Y2H
32296183
Intra
ANKRD28 O15084 PPP6R3 Homo sapiens Q5H9R7
Anti Tag CoIP
24255178
Intra
ANKRD28 O15084 PPP6R3 Homo sapiens Q5H9R7
Anti Tag CoIP
35271311
Intra
ANKRD28 O15084 PPP6R3 Homo sapiens Q5H9R7
GMS
18186651
Intra
ANKRD28 O15084 PPP6R2 Homo sapiens O75170
Anti Tag CoIP
24255178
Intra
ANKRD28 O15084 PPP6R2 Homo sapiens O75170
BioID
24255178
Intra
ANKRD28 O15084 PPP6R2 Homo sapiens O75170
Anti Tag CoIP
35271311
Intra
ANKRD28 O15084 PPP6R1 Homo sapiens Q9UPN7
Anti Tag CoIP
18186651
Intra
ANKRD28 O15084 PPP6R1 Homo sapiens Q9UPN7
GMS
18186651
Intra
ANKRD28 O15084 PPP6R1 Homo sapiens Q9UPN7
BioID
24255178
Intra
ANKRD28 O15084 PPP6R1 Homo sapiens Q9UPN7
Anti Tag CoIP
35271311
Intra
ANKRD28 O15084 PPP6R1 Homo sapiens Q9UPN7
Anti Tag CoIP
24255178
Intra
ANKRD28 O15084 PPP6C Homo sapiens O00743
BioID
24255178
Intra
ANKRD28 O15084 PPP6C Homo sapiens O00743
Anti Tag CoIP
24255178
Intra
ANKRD28 O15084 PPP6C Homo sapiens O00743
Anti Tag CoIP
18186651
Intra
ANKRD28 O15084 PPP6C Homo sapiens O00743
Anti Tag CoIP
35271311
Intra
ANKRD28 O15084 PPP6C Homo sapiens O00743
GMS
18186651
Intra
ANKRD28 O15084 GADD45GIP1 Homo sapiens Q8TAE8
Validated Y2H
32296183
Intra
ANKRD28 O15084 TNKS2 Homo sapiens Q9H2K2
Y2H Fragment Pooling
23414517
Intra
ANKRD28 O15084 DOCK1 Homo sapiens Q14185
Anti Tag CoIP
19118547
Intra
ANKRD28 O15084 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
ANKRD28 O15084 THAP7 Homo sapiens Q9BT49
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Urethra Clear Cell Adenocarcinoma

  • Clear Cell Adenocarcinoma Of The Urethra

  • Urethral Clear Cell Adenocarcinoma
Urethra Adenocarcinoma

  • Adenocarcinoma Of The Urethra

  • Urethral Adenocarcinoma
Urethra Cancer

  • Cancer Of Urethra

  • Malignant Tumour Of Urethra

  • Malignant Urethral Neoplasm

  • Urethral Ca
Apolipoprotein C-Iii Deficiency

  • Hyperalphalipoproteinemia 2

  • HALP2
Cardiomyopathy, Familial Hypertrophic, 2

  • Hypertrophic Cardiomyopathy 2

  • CMH2

  • Cardiomyopathy, Hypertrophic, 2

  • Cardiomyopathy Familial Hypertrophic 2

  • Cardiomyopathy, Familial Hypertrophic 2

  • Cardiomyopathy, Hypertrophic, Familial, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00721 ANKRD28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ANKRD28 VGNC VGNC:59805
Rattus norvegicus ANKRD28 RGD RGD:1559931
Canis familiaris ANKRD28 VGNC VGNC:37893
Bos taurus ANKRD28 VGNC VGNC:25920
Mus musculus ANKRD28 MGD MGI:2145661
Macaca mulatta ANKRD28 VGNC VGNC:69731
Others ANKRD28 NCBI