TAP1 - transporter 1, ATP binding cassette subfamily B member Gene

Also Known as APT1; PSF1; ABC17; ABCB2; PSF-1; RING4; TAP1N; D6S114E; TAP1*0102N

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6890

About TAP1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,845,209-32,853,704 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 217 orthologues, 10 paralogues and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 57.6), appendix (RPKM 54.1) and 24 other tissues.

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

TAP1 Products (2)

mRNA	Protein	Name
NM_000593.6	NP_000584.3	antigen peptide transporter 1 isoform 1
NM_001292022.2	NP_001278951.1	antigen peptide transporter 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ABC-type peptide antigen transporter activity	IDA IDA: Inferred from direct assay	11133832	GOA
enables ABC-type peptide antigen transporter activity	IMP IMP: Inferred from mutant phenotype	25656091	GOA
enables ADP binding	IDA IDA: Inferred from direct assay	11532960	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	7673167	GOA
enables ATP binding	IMP IMP: Inferred from mutant phenotype	15793001	GOA
enables MHC class Ib protein binding	IPI IPI: Inferred from physical interaction	10605026	GOA
enables TAP2 binding	IPI IPI: Inferred from physical interaction	1538751	GOA
enables peptide antigen binding	IDA IDA: Inferred from direct assay	7500034	GOA
contributes to peptide transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	7673167	GOA
enables peptide transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	17418234	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12213826	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I	IDA IDA: Inferred from direct assay	11133832	GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I	IMP IMP: Inferred from mutant phenotype	11133832	GOA
involved in cytosol to endoplasmic reticulum transport	IMP IMP: Inferred from mutant phenotype	7538543	GOA
involved in peptide transport	IMP IMP: Inferred from mutant phenotype	11133832	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of MHC class I peptide loading complex	IDA IDA: Inferred from direct assay	17947644	GOA
part of TAP complex	IDA IDA: Inferred from direct assay	11133832	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	7673167	GOA
located in membrane	IDA IDA: Inferred from direct assay	8955196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAP1 Protein Structure

ABC_membrane

ABC_tran

0
200
400
600
808 a.a.

Protein Preferred Names	Protein Names
antigen peptide transporter 1	ABC transporter, MHC 1

TAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TAP1	Q03518	CALR	Homo sapiens	P27797	Anti Bait CoIP	17055437
Intra	TAP1	Q03518	LCE2C	Homo sapiens	Q5TA81	Validated Y2H	32296183
Intra	TAP1	Q03518	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	TAP1	Q03518	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	TAP1	Q03518	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TAP1	Q03518	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TAP1	Q03518	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	TAP1	Q03518	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	TAP1	Q03518	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	TAP1	Q03518	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	TAP1	Q03518	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	TAP1	Q03518	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	TAP1	Q03518	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	TAP1	Q03518	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TAP1	Q03518	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	TAP1	Q03518	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	TAP1	Q03518	GEMIN4	Homo sapiens	P57678	Y2H Array	32296183
Intra	TAP1	Q03518	GEMIN4	Homo sapiens	P57678	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	SLC10A1	Homo sapiens	Q14973	Validated Y2H	32296183
Intra	TAP1	Q03518	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	TAP1	Q03518	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	P4HB	Homo sapiens	P07237	Anti Bait CoIP	17055437
Intra	TAP1	Q03518	THOC5	Homo sapiens	Q13769	Y2H	19165146
Intra	TAP1	Q03518	THOC5	Homo sapiens	Q13769	Pull Down	19165146
Intra	TAP1	Q03518	TAP2	Homo sapiens	Q03519	Anti Bait CoIP	19201886
Intra	TAP1	Q03518	TAP2	Homo sapiens	Q03519	Crosslink	19297616
Intra	TAP1	Q03518	TAP2	Homo sapiens	Q03519	Anti Bait CoIP	17055437
Intra	TAP1	Q03518	TAP2	Homo sapiens	Q03519	Anti Tag CoIP	18802093
Intra	TAP1	Q03518	TAP2	Homo sapiens	Q03519	Pull Down	26789246
Intra	TAP1	Q03518	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TAP1	Q03518	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TAP1	Q03518	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TAP1	Q03518	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	TAP1	Q03518	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	TAP1	Q03518	TAPBP	Homo sapiens	O15533	Anti Tag CoIP	18802093
Intra	TAP1	Q03518	TAPBP	Homo sapiens	O15533	Anti Bait CoIP	19201886
Intra	TAP1	Q03518	TAPBP	Homo sapiens	O15533	Anti Bait CoIP	17055437
Intra	TAP1	Q03518	PDIA3	Homo sapiens	P30101	Anti Bait CoIP	17055437
Intra	TAP1	Q03518	PDIA3	Homo sapiens	P30101	Pull Down	30833792
Cross	TAP1	Q03518	gN	Bovine herpesvirus 1.1	Q77CE4	Anti Bait CoIP	18802093
Cross	TAP1	Q03518	gN	Bovine herpesvirus 1.1	Q77CE4	Anti Tag CoIP	18802093
Cross	TAP1	Q03518	bnl2a_ebvb9	Epstein-Barr virus	P0C739	Anti Bait CoIP	19201886
Cross	TAP1	Q03518	bnl2a_ebvb9	Epstein-Barr virus	P0C739	IF	19201886

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bare Lymphocyte Syndrome, Type I	Hla Class I Deficiency Mhc Class I Deficiency Bls, Type I Bare Lymphocyte Syndrome Type I Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency Blsi Mhc Class 1 Deficiency Major Histocompatibility Complex Class 1 Deficiency Bare Lymphocyte Syndrome 1 BLS1 Bls I Bls Type I Bl-1 Bare Lymphocyte Syndrome Type 1 Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1 Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens Bls - [Bare Lymphocyte Syndrome] Nos
Immunodeficiency By Defective Expression Of Mhc Class I	Bare Lymphocyte Syndrome Type 1 Mhc Class I Deficiency
Spondylitis
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Diabetes Mellitus	Diabetes
Suppressor Of Tumorigenicity 3	Cervical Carcinoma ST3 Tumor-Suppressor Gene, Hela Cell Type Tshl Cervical Carcinoma, Tumor-Suppressor Gene Involved In Ccts Cervix Carcinoma
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14201	TAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17593	Tap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-D3417	BO-TAP-1		/	Unkown
HY-P5865	Tap1a	Inhibitor	/	Unkown
HY-RS12607	SEC14L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24053	Tap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAP1	VGNC	VGNC:35598
Mus musculus	TAP1	MGD	MGI:98483
Rattus norvegicus	TAP1	RGD	RGD:3817
Canis familiaris	TAP1	VGNC	VGNC:47105
Others	TAP1	NCBI