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Art. -Nr.: HY-N19214

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Glenthmycin L

Glenthmycin L is a potent antibiotic that can be found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin L exhibits antibacterial activity against Gram-positive bacterial pathogens including Staphylococcus aureus, Enterococcus faecalis, Methicillin (HY-B0974)-resistant Staphylococcus aureus, and Vancomycin (HY-B0671)-resistant Enterococci. Glenthmycin L can be used for the research of bacterial infections caused by Gram-positive pathogens.

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CAS. Nr.: 3040055-91-9
Formel: C₃₅H₄₆O₆
Molecular Weight:562.75

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Glenthmycin L Chemical Structure

CAS. Nr.: 3040055-91-9

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Biologische Aktivität
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Bioz

Biologische Aktivität

Beschreibung

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

Glenthmycin L (0.01-30 μM; 16-24 h) potently inhibits growth of Staphylococcus aureus (ATCC 25923) with an IC₅₀ of 0.8 μM, methicillin-resistant S. aureus (ATCC 43300) with an IC₅₀ of 0.3 μM, Enterococcus faecalis with an IC₅₀ of 3.0 μM, methicillin-resistant S. aureus (ATCC 33591) with an IC₅₀ of 6.8 μM, and vancomycin-resistant Enterococci with an IC₅₀ of 6.7 μM^[1].
Glenthmycin L (30 μM; 48 h) shows no significant cytotoxicity against SW620 human colorectal carcinoma cells or NCI-H460 human lung carcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SW620 human colorectal carcinoma cells, NCI-H460 human lung carcinoma cells
Concentration:

30 μM
Incubation Time:

48 h
Result:

Did not exhibit significant cytotoxicity against SW620 or NCI-H460 cells.
Showed no indication of reduced cell viability relative to the negative control.

Chemical Information

CAS. Nr. 3040055-91-9
Molecular Weight 562.75
Formel C₃₅H₄₆O₆
SMILES

OC=1[C@@]23[C@@](C=C(C)[C@H](C)C2)(/C=C(\C)/CC/C=C(\C)/[C@]4([C@@](C)(C(=O)C1C(=O)O3)[C@]5([C@@]([C@@H](OC(C)=O)CC[C@@H]5C)(C=C4C)[H])[H])[H])[H]
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces sp.
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wu T, et al. Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived Streptomyces sp. CMB-PB041. J Nat Prod. 2022 Jun 24;85(6):1641-1657. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- In Vitro
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Glenthmycin L

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Glenthmycin L Related Classifications

HY-N19214 Related Classifications