hCYP3A4 Fluorogenic substrate 1
Based on 1 Customer Validation
hCYP3A4 Fluorogenic substrate 1 is a potrnt hCYP3A4 fluorogenic substrate with an Km value of 0.36 μM. hCYP3A4 Fluorogenic substrate 1 can be used for cell and in vivo imaging.
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- Reinheit: 99.07%
- CAS. Nr.: 186299-00-3
- Formel: C19H12FNO2
- Molecular Weight:305.30
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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CYP3A4 0.36 μM (Km) |
hCYP3A4 Fluorogenic substrate 1 (compound F8) (20 μM; 30 min) shows brightly fluorescent signals at the green channel in both living Hep3B2 cells and Huh-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[1]
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Dosage:10 mg/kg
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Administration:I.v.
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Result:Can be used as a probe substrate offers a highly efficient and easy-to-use approach for screening and characterizing hCYP3A4 inhibitors or time-dependent inactivators, which strongly facilitates hCYP3A4-mediated DDI studies.
Chemical Information
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CAS. Nr. 186299-00-3
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Appearance Solid
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Molecular Weight 305.30
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Formel C19H12FNO2
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Color White to off-white
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SMILES
O=C(C1=C2C(C3=O)=CC=CC2=CC=C1)N3CC4=CC=C(F)C=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 12.5 mg/mL (40.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
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- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2755 mL | 16.3773 mL | 32.7547 mL | 81.8867 mL |
| 5 mM | 0.6551 mL | 3.2755 mL | 6.5509 mL | 16.3773 mL | |
| 10 mM | 0.3275 mL | 1.6377 mL | 3.2755 mL | 8.1887 mL | |
| 15 mM | 0.2184 mL | 1.0918 mL | 2.1836 mL | 5.4591 mL | |
| 20 mM | 0.1638 mL | 0.8189 mL | 1.6377 mL | 4.0943 mL | |
| 25 mM | 0.1310 mL | 0.6551 mL | 1.3102 mL | 3.2755 mL | |
| 30 mM | 0.1092 mL | 0.5459 mL | 1.0918 mL | 2.7296 mL | |
| 40 mM | 0.0819 mL | 0.4094 mL | 0.8189 mL | 2.0472 mL |
hCYP3A4 Fluorogenic substrate 1 Related Classifications
HY-155002 Related Classifications
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